Detailed information of TA system TA186799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 308954..309746
• Replicon: chromosome
• Accession: NZ_CP068159
• Organism: Corynebacterium riegelii strain FDAARGOS_1114

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: I6I71_RS01470
• Protein ID: WP_201821733.1
• Coordinates: 309231..309746 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A1F1YL62
• Locus tag: I6I71_RS01465
• Protein ID: WP_070494841.1
• Coordinates: 308954..309238 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I71_RS01460	307831..308973	+	1143	WP_201821731.1	AAA family ATPase	-
I6I71_RS01465	308954..309238	+	285	WP_070494841.1	DUF1778 domain-containing protein	Antitoxin
I6I71_RS01470	309231..309746	+	516	WP_201821733.1	GNAT family N-acetyltransferase	Toxin
I6I71_RS01475	309761..311050	-	1290	WP_201821734.1	adenylosuccinate synthase	-
I6I71_RS01480	311152..311976	+	825	WP_201821736.1	hypothetical protein	-
I6I71_RS01485	312272..313114	+	843	WP_201821738.1	PRC and DUF2382 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-77)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 18797.53 Da
• Isoelectric Point: 8.1004

>T186799 WP_201821733.1 NZ_CP068159:309231-309746 [Corynebacterium riegelii]
MTDGILHEPRRIKKGDHLSNFSCGVDSLDEWLKRFALRNQRANNAVTYVTTLNDEVVGYYALASGGVSRETLPKDLPGGS
RPYDVPVIVLARFAVDSRAQGKGVGRSLLADMFRRALAAADIVGAMGILIHAHDESAKQFYLRHADFWEMPGEPLHLLLP
IKSIRAALESG

Nucleotide

• Length: 516 bp

>T186799 NZ_CP089772:c2976954-2976631 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10677.20 Da
• Isoelectric Point: 6.3829

>AT186799 WP_070494841.1 NZ_CP068159:308954-309238 [Corynebacterium riegelii]
MTLTKDKRLNLRTTAQQDQRLKRAAEVRAVSVSEFILKSAMAEAEKVLADRRWFELNAEDFAKFEQALDTPVDGTKLARL
LASESVFGKEFTLD

Nucleotide

• Length: 285 bp

>AT186799 NZ_CP089772:c2977279-2977034 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1F1YL62