Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3066911..3067746 Replicon chromosome
Accession NZ_CP068155
Organism Escherichia coli strain FDAARGOS_1077

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag I6I34_RS15945 Protein ID WP_151276018.1
Coordinates 3066911..3067288 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6I34_RS15950 Protein ID WP_001285580.1
Coordinates 3067378..3067746 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I34_RS15915 3062038..3063186 - 1149 WP_000905925.1 capsule polysaccharide transporter -
I6I34_RS15920 3063258..3064241 - 984 WP_001355482.1 KpsF/GutQ family sugar-phosphate isomerase -
I6I34_RS15925 3065052..3065222 - 171 Protein_2912 IS110 family transposase -
I6I34_RS15930 3065565..3066407 - 843 WP_001280493.1 DUF4942 domain-containing protein -
I6I34_RS15935 3066492..3066689 - 198 WP_023563519.1 DUF957 domain-containing protein -
I6I34_RS15940 3066765..3066914 - 150 Protein_2915 hypothetical protein -
I6I34_RS15945 3066911..3067288 - 378 WP_151276018.1 TA system toxin CbtA family protein Toxin
I6I34_RS15950 3067378..3067746 - 369 WP_001285580.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6I34_RS15955 3067825..3068046 - 222 WP_000691818.1 DUF987 domain-containing protein -
I6I34_RS15960 3068183..3068362 - 180 WP_001398324.1 hypothetical protein -
I6I34_RS15965 3068404..3069101 + 698 Protein_2920 IS1 family transposase -
I6I34_RS15970 3069910..3070134 + 225 WP_001395295.1 transposase -
I6I34_RS15975 3070136..3070915 - 780 Protein_2922 IS3 family transposase -
I6I34_RS15980 3071082..3072050 - 969 WP_023486738.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14049.06 Da        Isoelectric Point: 8.7453

>T186785 WP_151276018.1 NZ_CP068155:c3067288-3066911 [Escherichia coli]
MKTLPNTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVSFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T186785 NZ_CP089772:c2205035-2204739 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13670.43 Da        Isoelectric Point: 6.9462

>AT186785 WP_001285580.1 NZ_CP068155:c3067746-3067378 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADSYHLNQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT186785 NZ_CP089772:c2205283-2205032 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References