Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2388053..2388888 Replicon chromosome
Accession NZ_CP068155
Organism Escherichia coli strain FDAARGOS_1077

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag I6I34_RS12725 Protein ID WP_000854743.1
Coordinates 2388511..2388888 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6I34_RS12720 Protein ID WP_001285298.1
Coordinates 2388053..2388421 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I34_RS12690 2383951..2384415 + 465 WP_202020896.1 antirestriction protein -
I6I34_RS12695 2384502..2385674 + 1173 WP_000952428.1 IS21-like element ISEc62 family transposase -
I6I34_RS12700 2385674..2386468 + 795 WP_000544809.1 IS21-like element helper ATPase IstB -
I6I34_RS12705 2386580..2387056 + 477 WP_001186774.1 RadC family protein -
I6I34_RS12710 2387119..2387340 + 222 WP_000692307.1 DUF987 domain-containing protein -
I6I34_RS12715 2387359..2388003 + 645 WP_000086754.1 hypothetical protein -
I6I34_RS12720 2388053..2388421 + 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6I34_RS12725 2388511..2388888 + 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
I6I34_RS12730 2388885..2389373 + 489 WP_000761693.1 hypothetical protein -
I6I34_RS12735 2389385..2389582 + 198 WP_000839275.1 DUF957 domain-containing protein -
I6I34_RS12740 2389679..2390517 + 839 Protein_2300 DUF4942 domain-containing protein -
I6I34_RS12745 2391313..2392497 + 1185 WP_001172882.1 sugar efflux transporter -
I6I34_RS12750 2392608..2393531 + 924 WP_000535961.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2350295..2390517 40222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T186781 WP_000854743.1 NZ_CP068155:2388511-2388888 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T186781 NZ_CP089772:c1941693-1941304 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT186781 WP_001285298.1 NZ_CP068155:2388053-2388421 [Escherichia coli]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp

>AT186781 NZ_CP089772:c1941917-1941690 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References