Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 901987..902605 Replicon chromosome
Accession NZ_CP068155
Organism Escherichia coli strain FDAARGOS_1077

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag I6I34_RS05515 Protein ID WP_001291435.1
Coordinates 902387..902605 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag I6I34_RS05510 Protein ID WP_000344800.1
Coordinates 901987..902361 (+) Length 125 a.a.

Genomic Context

I6I34_RS05500I6I34_RS05505I6I34_RS05510I6I34_RS05515I6I34_RS05520I6I34_RS05525I6I34_RS05530I6I34_RS05545I6I34_RS05535I6I34_RS05550
Location: 897076..898269 (1194 bp)
Type: Others
Protein ID: WP_001295324.1
Location: 898292..901441 (3150 bp)
Type: Others
Protein ID: WP_001132469.1
Location: 901987..902361 (375 bp)
Type: Antitoxin
Protein ID: WP_000344800.1
Location: 902387..902605 (219 bp)
Type: Toxin
Protein ID: WP_001291435.1
Location: 902777..903328 (552 bp)
Type: Others
Protein ID: WP_000102564.1
Location: 903444..903914 (471 bp)
Type: Others
Protein ID: WP_000136192.1
Location: 904078..905628 (1551 bp)
Type: Others
Protein ID: WP_001310610.1
Location: 906402..906713 (312 bp)
Type: Others
Protein ID: WP_000409911.1
Location: 905670..906023 (354 bp)
Type: Others
Protein ID: WP_000878143.1
Location: 906744..907316 (573 bp)
Type: Others
Protein ID: WP_000779831.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I34_RS05500897076..898269+1194WP_001295324.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
I6I34_RS05505898292..901441+3150WP_001132469.1multidrug efflux RND transporter permease subunit-
I6I34_RS05510901987..902361+375WP_000344800.1Hha toxicity modulator TomBAntitoxin
I6I34_RS05515902387..902605+219WP_001291435.1hemolysin expression modulator HhaToxin
I6I34_RS05520902777..903328+552WP_000102564.1maltose O-acetyltransferase-
I6I34_RS05525903444..903914+471WP_000136192.1YlaC family protein-
I6I34_RS05530904078..905628+1551WP_001310610.1cyclic-guanylate-specific phosphodiesterase PdeB-
I6I34_RS05535905670..906023-354WP_000878143.1DUF1428 domain-containing protein-
I6I34_RS05545906402..906713+312WP_000409911.1MGMT family protein-
I6I34_RS05550906744..907316-573WP_000779831.1YbaY family lipoprotein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T186776 WP_001291435.1 NZ_CP068155:902387-902605 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T186776 NZ_CP089772:c1392377-1392084 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT186776 WP_000344800.1 NZ_CP068155:901987-902361 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT186776 NZ_CP089772:c1392643-1392374 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB2MW2
PDB1JW2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U9QBQ5

References