Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3909501..3910297 Replicon chromosome
Accession NZ_CP068152
Organism Proteus mirabilis strain FDAARGOS_1079

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag I6I36_RS18115 Protein ID WP_036894284.1
Coordinates 3909501..3910013 (-) Length 171 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag I6I36_RS18120 Protein ID WP_036894282.1
Coordinates 3910010..3910297 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I36_RS18090 3905080..3905838 - 759 WP_004244974.1 DNA polymerase III subunit epsilon -
I6I36_RS18095 3905904..3906383 + 480 WP_004244975.1 ribonuclease HI -
I6I36_RS18100 3906408..3907121 - 714 WP_004244976.1 methyltransferase domain-containing protein -
I6I36_RS18105 3907159..3907914 + 756 WP_004252479.1 hydroxyacylglutathione hydrolase -
I6I36_RS18110 3907988..3909322 + 1335 WP_004247297.1 murein transglycosylase D -
I6I36_RS18115 3909501..3910013 - 513 WP_036894284.1 GNAT family N-acetyltransferase Toxin
I6I36_RS18120 3910010..3910297 - 288 WP_036894282.1 DUF1778 domain-containing protein Antitoxin
I6I36_RS18125 3910797..3912179 - 1383 WP_004247295.1 DASS family sodium-coupled anion symporter -
I6I36_RS18130 3912500..3913801 - 1302 WP_004244982.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-87)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18393.37 Da        Isoelectric Point: 9.5973

>T186770 WP_036894284.1 NZ_CP068152:c3910013-3909501 [Proteus mirabilis]
MTLKLTAPEPLKSVHLLEGFSSGEEALDLWLKNRAMSNQNSGASRTFVTTSDNQVMGYYALSTGVISTNQAVGRFRRNMP
TDIPVILLGRLAVDTRAKGLGIGRGLVKDACHRVIQASGLVGIRGVVVHALTDDAKRFYEHIGFLPSPLDPMMLMITLSD
LQLAMGISPN

Download         Length: 513 bp

>T186770 NZ_CP089772:843201-843629 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10717.15 Da        Isoelectric Point: 5.1972

>AT186770 WP_036894282.1 NZ_CP068152:c3910297-3910010 [Proteus mirabilis]
MPTQNDVSVTRSSLNLRIKPEDKILIDRAANAVGKNRTEFVLEAARRAAEETLADLRVINVSPEVYQEFISQLDSAPESN
EALRKTMMSKSPWEK

Download         Length: 288 bp

>AT186770 NZ_CP089772:842920-843177 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References