Detailed information of TA system TA186770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3909501..3910297
• Replicon: chromosome
• Accession: NZ_CP068152
• Organism: Proteus mirabilis strain FDAARGOS_1079

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: I6I36_RS18115
• Protein ID: WP_036894284.1
• Coordinates: 3909501..3910013 (-)
• Length: 171 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: I6I36_RS18120
• Protein ID: WP_036894282.1
• Coordinates: 3910010..3910297 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I36_RS18090	3905080..3905838	-	759	WP_004244974.1	DNA polymerase III subunit epsilon	-
I6I36_RS18095	3905904..3906383	+	480	WP_004244975.1	ribonuclease HI	-
I6I36_RS18100	3906408..3907121	-	714	WP_004244976.1	methyltransferase domain-containing protein	-
I6I36_RS18105	3907159..3907914	+	756	WP_004252479.1	hydroxyacylglutathione hydrolase	-
I6I36_RS18110	3907988..3909322	+	1335	WP_004247297.1	murein transglycosylase D	-
I6I36_RS18115	3909501..3910013	-	513	WP_036894284.1	GNAT family N-acetyltransferase	Toxin
I6I36_RS18120	3910010..3910297	-	288	WP_036894282.1	DUF1778 domain-containing protein	Antitoxin
I6I36_RS18125	3910797..3912179	-	1383	WP_004247295.1	DASS family sodium-coupled anion symporter	-
I6I36_RS18130	3912500..3913801	-	1302	WP_004244982.1	phosphopyruvate hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-87)

Sequences

Toxin

Protein

• Length: 171 a.a.
• Molecular weight: 18393.37 Da
• Isoelectric Point: 9.5973

>T186770 WP_036894284.1 NZ_CP068152:c3910013-3909501 [Proteus mirabilis]
MTLKLTAPEPLKSVHLLEGFSSGEEALDLWLKNRAMSNQNSGASRTFVTTSDNQVMGYYALSTGVISTNQAVGRFRRNMP
TDIPVILLGRLAVDTRAKGLGIGRGLVKDACHRVIQASGLVGIRGVVVHALTDDAKRFYEHIGFLPSPLDPMMLMITLSD
LQLAMGISPN

Nucleotide

• Length: 513 bp

>T186770 NZ_CP089772:843201-843629 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10717.15 Da
• Isoelectric Point: 5.1972

>AT186770 WP_036894282.1 NZ_CP068152:c3910297-3910010 [Proteus mirabilis]
MPTQNDVSVTRSSLNLRIKPEDKILIDRAANAVGKNRTEFVLEAARRAAEETLADLRVINVSPEVYQEFISQLDSAPESN
EALRKTMMSKSPWEK

Nucleotide

• Length: 288 bp

>AT186770 NZ_CP089772:842920-843177 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA