Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 1012194..1012893 Replicon chromosome
Accession NZ_CP068152
Organism Proteus mirabilis strain FDAARGOS_1079

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag I6I36_RS04725 Protein ID WP_004249093.1
Coordinates 1012507..1012893 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag I6I36_RS04720 Protein ID WP_004246828.1
Coordinates 1012194..1012514 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I36_RS04690 1007325..1007600 - 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -
I6I36_RS04695 1007655..1008278 - 624 WP_004246821.1 guanylate kinase -
I6I36_RS04700 1008579..1009196 - 618 WP_004246822.1 trimeric intracellular cation channel family protein -
I6I36_RS04705 1009333..1010619 + 1287 WP_004249090.1 DUF3748 domain-containing protein -
I6I36_RS04710 1010834..1011718 + 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
I6I36_RS04715 1011711..1012145 + 435 WP_004246827.1 hypothetical protein -
I6I36_RS04720 1012194..1012514 - 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
I6I36_RS04725 1012507..1012893 - 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I36_RS04730 1013055..1015127 - 2073 WP_201704658.1 glycine--tRNA ligase subunit beta -
I6I36_RS04735 1015137..1016042 - 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
I6I36_RS04740 1016293..1016874 + 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T186767 WP_004249093.1 NZ_CP068152:c1012893-1012507 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T186767 NZ_CP089772:c756913-756605 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT186767 WP_004246828.1 NZ_CP068152:c1012514-1012194 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT186767 NZ_CP089772:c757145-756900 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References