186764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 5709104..5709744 Replicon chromosome
Accession NZ_CP068151
Organism Pseudomonas fluorescens strain FDAARGOS_1088

Toxin (Protein)


Gene name vagD Uniprot ID A0A0W0MYI4
Locus tag I6I45_RS26030 Protein ID WP_014719602.1
Coordinates 5709331..5709744 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag I6I45_RS26025 Protein ID WP_103452516.1
Coordinates 5709104..5709334 (+) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I45_RS26005 5705362..5706321 + 960 WP_014719606.1 LysR family transcriptional regulator -
I6I45_RS26010 5706413..5707060 - 648 WP_020303103.1 HAD-IB family hydrolase -
I6I45_RS26015 5707133..5707306 - 174 Protein_5120 HNH endonuclease -
I6I45_RS26020 5707373..5708623 - 1251 WP_014719604.1 ribonucleotide-diphosphate reductase subunit beta -
I6I45_RS26025 5709104..5709334 + 231 WP_103452516.1 AbrB family transcriptional regulator Antitoxin
I6I45_RS26030 5709331..5709744 + 414 WP_014719602.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I45_RS26035 5709882..5710151 - 270 WP_014719601.1 DUF2790 domain-containing protein -
I6I45_RS26040 5710550..5712505 + 1956 WP_127882265.1 acetate--CoA ligase -
I6I45_RS26045 5713202..5713987 + 786 WP_020302951.1 ABC transporter substrate-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-129)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15188.53 Da        Isoelectric Point: 7.6998

>T186764 WP_014719602.1 NZ_CP068151:5709331-5709744 [Pseudomonas fluorescens]
VTTYMLDTCICSFIMRERPECVLKRLALEVARSNRIVISAITYAEMRYGQIGKKASSKHKTLVDEFVKRLDEVLPWGVAA
VDATVEVKRSLTEQGAIIGQNDTAIAGHAIASGCTLVTNNIREFSRVAGLSYEDWVH

Download         Length: 414 bp

>T186764 NZ_CP089772:718051-718446 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8653.71 Da        Isoelectric Point: 5.0651

>AT186764 WP_103452516.1 NZ_CP068151:5709104-5709334 [Pseudomonas fluorescens]
MRTVSIFKNGKNQAIRFPNDMAYEGVGELEITRNGDTITLRPVRPSWGSLSELPRADEDFLQKRQDVVGDEGRFNL

Download         Length: 231 bp

>AT186764 NZ_CP089772:717797-718051 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0W0MYI4


Antitoxin

Source ID Structure

References