Detailed information of TA system TA186761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2963369..2963816
• Replicon: chromosome
• Accession: NZ_CP068151
• Organism: Pseudomonas fluorescens strain FDAARGOS_1088

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6I45_RS13350
• Protein ID: WP_081088256.1
• Coordinates: 2963369..2963638 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0W0ND88
• Locus tag: I6I45_RS13355
• Protein ID: WP_014717050.1
• Coordinates: 2963628..2963816 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I45_RS13330	2959404..2960780	+	1377	WP_019817648.1	L-serine ammonia-lyase	-
I6I45_RS13335	2960842..2962131	+	1290	WP_014717054.1	HAAAP family serine/threonine permease	-
I6I45_RS13340	2962397..2962714	+	318	WP_014717053.1	DUF3509 domain-containing protein	-
I6I45_RS13345	2962711..2963199	-	489	WP_014717052.1	phosphate-starvation-inducible PsiE family protein	-
I6I45_RS13350	2963369..2963638	-	270	WP_081088256.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I45_RS13355	2963628..2963816	-	189	WP_014717050.1	hypothetical protein	Antitoxin
I6I45_RS13360	2963968..2964213	-	246	WP_014717049.1	hypothetical protein	-
I6I45_RS13365	2964634..2964894	+	261	WP_003188807.1	YebG family protein	-
I6I45_RS13370	2964950..2965969	-	1020	WP_014717048.1	Glu/Leu/Phe/Val dehydrogenase	-
I6I45_RS13375	2966156..2966959	+	804	WP_020301219.1	tetratricopeptide repeat protein	-
I6I45_RS13380	2966945..2968276	-	1332	WP_201915597.1	aromatic acid/H+ symport family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10355.16 Da
• Isoelectric Point: 10.9886

>T186761 WP_081088256.1 NZ_CP068151:c2963638-2963369 [Pseudomonas fluorescens]
MLIEWSPAARVELRQIIEYLSHRNPVAALELKRSIEASVLALSRRPHLYRPGRIGGTREMVVHPNYLVVYKVTDNIRILS
VLHARQRYP

Nucleotide

• Length: 270 bp

>T186761 NZ_CP089772:c698954-698541 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6884.55 Da
• Isoelectric Point: 4.0061

>AT186761 WP_014717050.1 NZ_CP068151:c2963816-2963628 [Pseudomonas fluorescens]
MDTSFSSGIQADIEEQADSYDRWFRARVQAALDDPSPGIPHDEVMAEMQALIESKLKKGDAD

Nucleotide

• Length: 189 bp

>AT186761 NZ_CP089772:c699187-698951 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0W0ND88