186759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 663575..664188 Replicon chromosome
Accession NZ_CP068151
Organism Pseudomonas fluorescens strain FDAARGOS_1088

Toxin (Protein)


Gene name hicA Uniprot ID A0A0W0N4L4
Locus tag I6I45_RS03200 Protein ID WP_014718823.1
Coordinates 663937..664188 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A854B833
Locus tag I6I45_RS03195 Protein ID WP_014718824.1
Coordinates 663575..663940 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I45_RS03175 659432..660262 + 831 WP_019816829.1 IclR family transcriptional regulator -
I6I45_RS03180 660343..661698 + 1356 WP_201914816.1 MATE family efflux transporter -
I6I45_RS03185 661682..662269 - 588 WP_032905010.1 TetR/AcrR family transcriptional regulator -
I6I45_RS03190 662402..663574 + 1173 WP_014718825.1 MFS transporter -
I6I45_RS03195 663575..663940 - 366 WP_014718824.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6I45_RS03200 663937..664188 - 252 WP_014718823.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9526.11 Da        Isoelectric Point: 10.0459

>T186759 WP_014718823.1 NZ_CP068151:c664188-663937 [Pseudomonas fluorescens]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDMGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T186759 NZ_CP089772:679309-679716 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13248.12 Da        Isoelectric Point: 7.3725

>AT186759 WP_014718824.1 NZ_CP068151:c663940-663575 [Pseudomonas fluorescens]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFRGAVDDYLATCQSLGHTPEKPCKGSFNVRVGH
DLHLAAALAANRKKVTLNDLTRQALNEFLQHHYPEPCPTIG

Download         Length: 366 bp

>AT186759 NZ_CP089772:679097-679312 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0N4L4

Antitoxin

Source ID Structure
AlphaFold DB A0A854B833

References