Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4708422..4709002 Replicon chromosome
Accession NZ_CP068148
Organism Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)


Gene name relE Uniprot ID A0A515D1D0
Locus tag I6I38_RS21920 Protein ID WP_046374632.1
Coordinates 4708422..4708706 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7W4F292
Locus tag I6I38_RS21925 Protein ID WP_020824985.1
Coordinates 4708715..4709002 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I38_RS21900 4703828..4704352 - 525 WP_020824990.1 NAD(P)H-dependent oxidoreductase -
I6I38_RS21905 4704457..4705365 + 909 WP_187962185.1 LysR family transcriptional regulator -
I6I38_RS21910 4705649..4707787 + 2139 WP_020824988.1 anaerobic ribonucleoside-triphosphate reductase -
I6I38_RS21915 4707961..4708425 + 465 WP_116691389.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6I38_RS21920 4708422..4708706 - 285 WP_046374632.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
I6I38_RS21925 4708715..4709002 - 288 WP_020824985.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6I38_RS21930 4709107..4710165 - 1059 WP_046374633.1 permease -
I6I38_RS21935 4710426..4711151 + 726 WP_201896494.1 phosphonate metabolism transcriptional regulator PhnF -
I6I38_RS21940 4711152..4711595 + 444 WP_046374634.1 phosphonate C-P lyase system protein PhnG -
I6I38_RS21945 4711598..4712179 + 582 WP_201895804.1 phosphonate C-P lyase system protein PhnH -
I6I38_RS21950 4712179..4713264 + 1086 WP_201895805.1 carbon-phosphorus lyase complex subunit PhnI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4697480..4709002 11522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-44)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11173.88 Da        Isoelectric Point: 4.7160

>T186756 WP_046374632.1 NZ_CP068148:c4708706-4708422 [Serratia liquefaciens]
MRVEWDEEALRDRERIFDFLYPFNPQVAEQADAEIDKAVKRLLDYPELGKIWYRQARKLLVSQASLIVLYVVVDDVIKVL
AVVHQREKFPDIEN

Download         Length: 285 bp

>T186756 NZ_CP089772:367978-368403 [Mycobacterium tuberculosis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11043.40 Da        Isoelectric Point: 6.4766

>AT186756 WP_020824985.1 NZ_CP068148:c4709002-4708715 [Serratia liquefaciens]
MESRIQFRIEDETKRLAQKAAEAKGITLSEACRRLAEQMADEQRATEQHENWLKEKVDAAFARLHEGSAVYLDQQQVDES
MDAFKAKVRAKYDRK

Download         Length: 288 bp

>AT186756 NZ_CP089772:367760-367981 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A515D1D0

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4F292

References