Detailed information of TA system TA186755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4653415..4654964
• Replicon: chromosome
• Accession: NZ_CP068148
• Organism: Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6I38_RS21675
• Protein ID: WP_201895793.1
• Coordinates: 4653415..4654713 (-)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6I38_RS21680
• Protein ID: WP_201895794.1
• Coordinates: 4654716..4654964 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I38_RS21665	4649090..4652275	+	3186	WP_201895791.1	HsdR family type I site-specific deoxyribonuclease	-
I6I38_RS21670	4652552..4653286	+	735	WP_201895792.1	hypothetical protein	-
I6I38_RS21675	4653415..4654713	-	1299	WP_201895793.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6I38_RS21680	4654716..4654964	-	249	WP_201895794.1	helix-turn-helix domain-containing protein	Antitoxin
I6I38_RS21685	4655189..4655824	-	636	WP_012005022.1	carbonic anhydrase	-
I6I38_RS21695	4656705..4657775	-	1071	WP_020825022.1	LPS export ABC transporter permease LptG	-
I6I38_RS21700	4657775..4658869	-	1095	WP_020825021.1	LPS export ABC transporter permease LptF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4641161..4654964	13803

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48587.69 Da
• Isoelectric Point: 5.6453

>T186755 WP_201895793.1 NZ_CP068148:c4654713-4653415 [Serratia liquefaciens]
MEKLRVALNGTLVGMLEKHAGGVMSFVYQEEWLAQAGSRAISLSLPLQPEPFRGDVVYNFFDNLLPDSELIRSRIQARFR
TVTKQPFDLLSSIGSDCVGAIQLYPEHAEVAPVKQVNAVPISDEEIEQLLEGYREAPLGMGPDIDDFRISLAGAQEKTAL
LWFDNQWYRPEGSTPTSHILKLPIGHIAHNNLDLSESCENEWLCLRMAEQFGLPVAQTQLAHFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGITAAMELLLGSQQPLLDRDTFFKSQIVFWMLAAIDGHAKNFSLFLQPE
TTYRMTPLYDVLSGYPFMHARGIAPQKAKMAMAAIGKGRHYRWSQILPRHFISTARAVGYSEEKTLQVMAELKAQTDQAI
ANVEAMLPDDFPRFVRDAIFAGVRRQAERLPG

Nucleotide

• Length: 1299 bp

>T186755 NZ_CP089772:367410-367712 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9293.59 Da
• Isoelectric Point: 10.3139

>AT186755 WP_201895794.1 NZ_CP068148:c4654964-4654716 [Serratia liquefaciens]
MKITSAQMLAHTLRNERKKRNQSQSKTADSVGLKQATISAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Nucleotide

• Length: 249 bp

>AT186755 NZ_CP089772:367760-367981 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA