Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1984656..1985281 Replicon chromosome
Accession NZ_CP068148
Organism Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I6I38_RS09125 Protein ID WP_201896284.1
Coordinates 1985099..1985281 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6I38_RS09120 Protein ID WP_128864764.1
Coordinates 1984656..1985069 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I38_RS09090 1979881..1980603 + 723 WP_020827491.1 RNA polymerase sigma factor FliA -
I6I38_RS09095 1980662..1981171 + 510 WP_130016327.1 flagella biosynthesis regulatory protein FliZ -
I6I38_RS09100 1981299..1982291 + 993 WP_122079693.1 D-cysteine desulfhydrase -
I6I38_RS09105 1982406..1983206 + 801 WP_046373262.1 cystine ABC transporter substrate-binding protein -
I6I38_RS09110 1983206..1983868 + 663 WP_020827487.1 cystine ABC transporter permease -
I6I38_RS09115 1983872..1984624 + 753 WP_046373263.1 L-cystine ABC transporter ATP-binding protein YecC -
I6I38_RS09120 1984656..1985069 - 414 WP_128864764.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6I38_RS09125 1985099..1985281 - 183 WP_201896284.1 type II toxin-antitoxin system HicA family toxin Toxin
I6I38_RS09130 1985448..1989419 - 3972 WP_046373266.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6782.98 Da        Isoelectric Point: 10.7801

>T186744 WP_201896284.1 NZ_CP068148:c1985281-1985099 [Serratia liquefaciens]
VKSSELIGLLEQEGWVLTRIKGSHHQFKHPNSRLVITVPHPRKDLKAATLRQIMKDAGLC

Download         Length: 183 bp

>T186744 NZ_CP089771:c645911-645543 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15092.77 Da        Isoelectric Point: 5.0911

>AT186744 WP_128864764.1 NZ_CP068148:c1985069-1984656 [Serratia liquefaciens]
MFYPAYVHSEPNGSASGFFPDVPGCYFAGDTLDRAFEDARSALDAHFEFLSEDNQPIPGPQAVTFHLAQNNDSLNGGQWL
LVNINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Download         Length: 414 bp

>AT186744 NZ_CP089771:c646129-645908 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References