Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1217653..1218254 Replicon chromosome
Accession NZ_CP068148
Organism Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag I6I38_RS05540 Protein ID WP_201896126.1
Coordinates 1217871..1218254 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag I6I38_RS05535 Protein ID WP_201896125.1
Coordinates 1217653..1217874 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I38_RS05510 1212815..1213018 + 204 WP_201896122.1 hypothetical protein -
I6I38_RS05515 1213018..1213821 + 804 WP_201896123.1 DUF4406 domain-containing protein -
I6I38_RS05520 1214309..1216555 + 2247 WP_201896444.1 replication endonuclease -
I6I38_RS05525 1216569..1216748 + 180 WP_201896124.1 hypothetical protein -
I6I38_RS05530 1216858..1217586 + 729 WP_201896445.1 DNA adenine methylase -
I6I38_RS05535 1217653..1217874 + 222 WP_201896125.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6I38_RS05540 1217871..1218254 + 384 WP_201896126.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6I38_RS05545 1218652..1219704 - 1053 WP_201896127.1 phage portal protein -
I6I38_RS05550 1219707..1221425 - 1719 WP_201896128.1 terminase family protein -
I6I38_RS05555 1221572..1222411 + 840 WP_201896129.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1207273..1240429 33156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-60)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14031.02 Da        Isoelectric Point: 5.1528

>T186743 WP_201896126.1 NZ_CP068148:1217871-1218254 [Serratia liquefaciens]
MKWISAQEVVAFHDRLLAALPGVPGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLIAIARGHIFNDGNKRTAFFVT
MAFLNRNGIQIRDEGNELEELTVSAATGAISTVEISAVLRQLSNASR

Download         Length: 384 bp

>T186743 NZ_CP089771:c162478-162068 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8140.09 Da        Isoelectric Point: 5.0644

>AT186743 WP_201896125.1 NZ_CP068148:1217653-1217874 [Serratia liquefaciens]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDTEFAEIMGRHGRTIKALADR

Download         Length: 222 bp

>AT186743 NZ_CP089771:c162725-162459 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References