Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1154117..1154769 Replicon chromosome
Accession NZ_CP068148
Organism Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YFT9
Locus tag I6I38_RS05230 Protein ID WP_020828096.1
Coordinates 1154383..1154769 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YGI8
Locus tag I6I38_RS05225 Protein ID WP_020828097.1
Coordinates 1154117..1154380 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I38_RS05210 1150383..1151300 - 918 WP_020828101.1 lipid kinase YegS -
I6I38_RS05215 1151775..1153127 - 1353 WP_041414820.1 tRNA 5-hydroxyuridine modification protein YegQ -
I6I38_RS05220 1153428..1153766 - 339 WP_020828098.1 YegP family protein -
I6I38_RS05225 1154117..1154380 + 264 WP_020828097.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I38_RS05230 1154383..1154769 + 387 WP_020828096.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I38_RS05235 1154776..1155492 - 717 WP_020828095.1 two-component system response regulator BaeR -
I6I38_RS05240 1155492..1156874 - 1383 WP_201896100.1 two-component system sensor histidine kinase BaeS -
I6I38_RS05245 1156874..1158304 - 1431 WP_020828093.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14093.28 Da        Isoelectric Point: 7.8799

>T186742 WP_020828096.1 NZ_CP068148:1154383-1154769 [Serratia liquefaciens]
MYMFDTNTVSQLFRRHPRLLSLMEKIPPSAVCISSITQAELLYGVAKRQNLALKATVAAFLDSVTVYAWDSEAAHCYGTL
RAEMTQKGRVMGALDQLIAAHAQSRGATIVTNDRAFAMVPGLTVEDWT

Download         Length: 387 bp

>T186742 NZ_CP089770:c87582-87328 [Klebsiella pneumoniae]
ATGAGAAAAAATAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10091.38 Da        Isoelectric Point: 5.8701

>AT186742 WP_020828097.1 NZ_CP068148:1154117-1154380 [Serratia liquefaciens]
MERVAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLQMIEKTQVPHDFLAADERQQGSATR
DPFAGEE

Download         Length: 264 bp

>AT186742 NZ_CP089770:c87331-87089 [Klebsiella pneumoniae]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YFT9

Antitoxin

Source ID Structure
AlphaFold DB A0A379YGI8

References