Detailed information of TA system TA186740

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 795919..796588
• Replicon: chromosome
• Accession: NZ_CP068148
• Organism: Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6I38_RS03595
• Protein ID: WP_128865160.1
• Coordinates: 796166..796588 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A7W4F6J9
• Locus tag: I6I38_RS03590
• Protein ID: WP_020828476.1
• Coordinates: 795919..796185 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I38_RS03565	791058..792383	+	1326	WP_122080133.1	MHS family MFS transporter	-
I6I38_RS03570	792424..793032	-	609	WP_048760837.1	HD domain-containing protein	-
I6I38_RS03575	793216..793890	+	675	WP_020828479.1	hemolysin III family protein	-
I6I38_RS03580	794055..794552	+	498	WP_020828478.1	DUF2165 domain-containing protein	-
I6I38_RS03585	794610..795596	-	987	WP_201896034.1	tRNA-modifying protein YgfZ	-
I6I38_RS03590	795919..796185	+	267	WP_020828476.1	FAD assembly factor SdhE	Antitoxin
I6I38_RS03595	796166..796588	+	423	WP_128865160.1	protein YgfX	Toxin
I6I38_RS03600	796588..797283	+	696	WP_129984121.1	two-component system response regulator CreB	-
I6I38_RS03605	797280..798698	+	1419	WP_142814474.1	two-component system sensor histidine kinase CreC	-
I6I38_RS03610	798783..800147	+	1365	WP_122080129.1	cell envelope integrity protein CreD	-
I6I38_RS03615	800184..800702	-	519	WP_020828471.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16549.49 Da
• Isoelectric Point: 10.6957

>T186740 WP_128865160.1 NZ_CP068148:796166-796588 [Serratia liquefaciens]
VAQWRCDVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLENQRVGWQGQ
EWQLAKQPWMLRFGILLTLQPMQGKKRRRLWLASDSMAKAEWRHLRQQLLYPPASDDEEP

Nucleotide

• Length: 423 bp

>T186740 NZ_CP089769:55879-56361 [Klebsiella pneumoniae]
ATGGGAATGAGGCCTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAATCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTAGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCACTGACATTATTATTTCCGATCAAAACA
TGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.99 Da
• Isoelectric Point: 5.0990

>AT186740 WP_020828476.1 NZ_CP068148:795919-796185 [Serratia liquefaciens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDRLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT186740 NZ_CP089769:55610-55888 [Klebsiella pneumoniae]
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGCTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7W4F6J9