Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4050518..4051478 Replicon chromosome
Accession NZ_CP068147
Organism Yersinia enterocolitica strain FDAARGOS_1090

Toxin (Protein)


Gene name - Uniprot ID A0A7U7FM81
Locus tag I6I47_RS18315 Protein ID WP_013649871.1
Coordinates 4051020..4051478 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7U7FM48
Locus tag I6I47_RS18310 Protein ID WP_013649872.1
Coordinates 4050518..4050964 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I47_RS18290 4046043..4046750 + 708 WP_005160995.1 murein tripeptide amidase MpaA -
I6I47_RS18295 4046747..4047718 - 972 WP_013649874.1 L-Ala-D/L-Glu epimerase -
I6I47_RS18300 4047871..4048374 + 504 WP_005161000.1 thiol peroxidase -
I6I47_RS18305 4048621..4050198 - 1578 WP_020283144.1 transcriptional regulator TyrR -
I6I47_RS18310 4050518..4050964 + 447 WP_013649872.1 DUF2384 domain-containing protein Antitoxin
I6I47_RS18315 4051020..4051478 + 459 WP_013649871.1 RES family NAD+ phosphorylase Toxin
I6I47_RS18320 4051481..4052545 - 1065 WP_013649870.1 YcjF family protein -
I6I47_RS18325 4052542..4053939 - 1398 WP_005161012.1 YcjX family protein -
I6I47_RS18330 4053920..4054159 - 240 WP_005161016.1 phage shock protein PspD -
I6I47_RS18335 4054205..4054609 - 405 WP_013649869.1 envelope stress response membrane protein PspC -
I6I47_RS18340 4054609..4054836 - 228 WP_005161022.1 envelope stress response membrane protein PspB -
I6I47_RS18345 4054998..4055663 - 666 WP_005161029.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17158.54 Da        Isoelectric Point: 4.6717

>T186729 WP_013649871.1 NZ_CP068147:4051020-4051478 [Yersinia enterocolitica]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Download         Length: 459 bp

>T186729 NZ_CP089768:413215-413538 [Klebsiella pneumoniae]
ATGAAATTTCTACCTACAACAAATATGCGGGCGGCGAAGCCATGCTTGTCGCCCGTGACTATCTGGCAAATGCTACTTAG
TCGTCTGCTGGAACAGCATTATGGCCTGACACTAAACGATACACCTTTCTGTGATGAAACCGTCATACAGGAACATATCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTCGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGGGCCCGTCGCGATCTGGGTTTAATGAATCGTAA
TTAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16322.77 Da        Isoelectric Point: 9.8753

>AT186729 WP_013649872.1 NZ_CP068147:4050518-4050964 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Download         Length: 447 bp

>AT186729 NZ_CP089768:412838-413194 [Klebsiella pneumoniae]
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATCCCCCCTGCCAGCAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCACGTCTGGTGCAGGAAGGCGACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAACGGTGCTTTCA
GCGACGAGCATGCGTTGCGCCTCGACCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGCTGATACTCACCAGCGGAGAA
CTCTCCCCCCGCCATCAGCACTGTGTCACCCTCTATCACAACGGACTCACCTGCGAAGCCGATACGCTTGGTAGTTGTGG
CTACGTATACATCGCCATTTATCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FM81

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FM48

References