Detailed information of TA system TA186725

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2529598..2530270
• Replicon: chromosome
• Accession: NZ_CP068147
• Organism: Yersinia enterocolitica strain FDAARGOS_1090

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7U7FIQ4
• Locus tag: I6I47_RS11300
• Protein ID: WP_005166047.1
• Coordinates: 2529845..2530270 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: I6I47_RS11295
• Protein ID: WP_013649338.1
• Coordinates: 2529598..2529864 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I47_RS11270	2525376..2525813	+	438	WP_013649333.1	lipocalin-like domain-containing protein	-
I6I47_RS11275	2525829..2526578	+	750	WP_013649334.1	SDR family oxidoreductase	-
I6I47_RS11280	2526591..2527193	-	603	WP_005164134.1	HD domain-containing protein	-
I6I47_RS11285	2527424..2528107	+	684	WP_005180855.1	hemolysin III family protein	-
I6I47_RS11290	2528339..2529331	-	993	WP_005166051.1	tRNA-modifying protein YgfZ	-
I6I47_RS11295	2529598..2529864	+	267	WP_013649338.1	FAD assembly factor SdhE	Antitoxin
I6I47_RS11300	2529845..2530270	+	426	WP_005166047.1	protein YgfX	Toxin
I6I47_RS11305	2530270..2530968	+	699	WP_005166045.1	two-component system response regulator CreB	-
I6I47_RS11310	2530979..2532406	+	1428	WP_013649340.1	two-component system sensor histidine kinase CreC	-
I6I47_RS11315	2532498..2533919	+	1422	WP_013649341.1	cell envelope integrity protein CreD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2534050..2535486	1436

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16425.21 Da
• Isoelectric Point: 9.8217

>T186725 WP_005166047.1 NZ_CP068147:2529845-2530270 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Nucleotide

• Length: 426 bp

>T186725 NZ_CP089766:19485-19967 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10519.06 Da
• Isoelectric Point: 5.1405

>AT186725 WP_013649338.1 NZ_CP068147:2529598-2529864 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KVRGPVAM

Nucleotide

• Length: 267 bp

>AT186725 NZ_CP089766:19231-19497 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: A0A7U7FIQ4