Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2185632..2186167 Replicon chromosome
Accession NZ_CP068147
Organism Yersinia enterocolitica strain FDAARGOS_1090

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7FI46
Locus tag I6I47_RS09910 Protein ID WP_005156226.1
Coordinates 2185880..2186167 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag I6I47_RS09905 Protein ID WP_005156229.1
Coordinates 2185632..2185883 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I47_RS09880 2180849..2181733 + 885 WP_005156239.1 sugar ABC transporter permease -
I6I47_RS09885 2181752..2182591 + 840 WP_005156238.1 carbohydrate ABC transporter permease -
I6I47_RS09890 2182603..2183718 + 1116 WP_005156237.1 ABC transporter ATP-binding protein -
I6I47_RS09895 2183732..2184898 + 1167 WP_013649156.1 alginate lyase family protein -
I6I47_RS09900 2184972..2185424 + 453 WP_005181269.1 YhbP family protein -
I6I47_RS09905 2185632..2185883 + 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6I47_RS09910 2185880..2186167 + 288 WP_005156226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I47_RS09915 2186243..2186872 + 630 WP_005175332.1 hypothetical protein -
I6I47_RS09920 2186873..2187640 - 768 WP_005156220.1 phosphonate metabolism protein PhnP -
I6I47_RS09925 2187631..2188209 - 579 WP_020282482.1 ribose 1,5-bisphosphokinase -
I6I47_RS09930 2188209..2189357 - 1149 WP_020282483.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
I6I47_RS09935 2189354..2190088 - 735 WP_032904377.1 phosphonate C-P lyase system protein PhnL -
I6I47_RS09940 2190102..2190908 - 807 WP_013649159.1 phosphonate C-P lyase system protein PhnK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11002.07 Da        Isoelectric Point: 10.3544

>T186724 WP_005156226.1 NZ_CP068147:2185880-2186167 [Yersinia enterocolitica]
MIYKVKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T186724 NZ_CP089765:c4473259-4471937 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT186724 WP_005156229.1 NZ_CP068147:2185632-2185883 [Yersinia enterocolitica]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT186724 NZ_CP089765:c4473525-4473259 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FI46

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References