Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1526762..1527405 Replicon chromosome
Accession NZ_CP068147
Organism Yersinia enterocolitica strain FDAARGOS_1090

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag I6I47_RS06935 Protein ID WP_005161957.1
Coordinates 1526762..1527181 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag I6I47_RS06940 Protein ID WP_005161959.1
Coordinates 1527178..1527405 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I47_RS06915 1521981..1522835 + 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -
I6I47_RS06920 1522962..1523585 + 624 WP_013650637.1 superoxide dismutase [Mn] -
I6I47_RS06925 1523909..1525858 + 1950 WP_005161951.1 methyl-accepting chemotaxis protein -
I6I47_RS06930 1525937..1526608 + 672 WP_005161954.1 6-N-hydroxylaminopurine resistance protein -
I6I47_RS06935 1526762..1527181 - 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I47_RS06940 1527178..1527405 - 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I47_RS06945 1527537..1527893 - 357 WP_005161962.1 YibL family ribosome-associated protein -
I6I47_RS06950 1527986..1529467 - 1482 WP_005161967.1 PLP-dependent aminotransferase family protein -
I6I47_RS06955 1529735..1530346 + 612 WP_016266331.1 LysE family translocator -
I6I47_RS06960 1530343..1530897 - 555 WP_020283571.1 MltR family transcriptional regulator -
I6I47_RS06965 1531128..1532291 - 1164 WP_013650643.1 mannitol-1-phosphate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T186722 WP_005161957.1 NZ_CP068147:c1527181-1526762 [Yersinia enterocolitica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

>T186722 NZ_CP089765:2527002-2527535 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT186722 WP_005161959.1 NZ_CP068147:c1527405-1527178 [Yersinia enterocolitica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT186722 NZ_CP089765:2526725-2526991 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References