Detailed information of TA system TA186721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1145378..1147007
• Replicon: chromosome
• Accession: NZ_CP068147
• Organism: Yersinia enterocolitica strain FDAARGOS_1090

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6I47_RS05280
• Protein ID: WP_020282667.1
• Coordinates: 1145679..1147007 (+)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6I47_RS05275
• Protein ID: WP_020282668.1
• Coordinates: 1145378..1145677 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I47_RS05260	1140823..1142472	-	1650	WP_020282670.1	Na+/H+ antiporter	-
I6I47_RS05265	1142684..1144051	-	1368	WP_005165212.1	NCS2 family permease	-
I6I47_RS05270	1144412..1145083	-	672	WP_013650521.1	glutathione S-transferase	-
I6I47_RS05275	1145378..1145677	+	300	WP_020282668.1	helix-turn-helix transcriptional regulator	Antitoxin
I6I47_RS05280	1145679..1147007	+	1329	WP_020282667.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6I47_RS05285	1147096..1147644	-	549	WP_005165221.1	single-stranded DNA-binding protein SSB1	-
I6I47_RS05290	1148173..1151004	+	2832	WP_013650522.1	excinuclease ABC subunit UvrA	-
I6I47_RS05295	1151063..1151416	-	354	WP_005165225.1	MmcQ/YjbR family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49939.96 Da
• Isoelectric Point: 6.8736

>T186721 WP_020282667.1 NZ_CP068147:1145679-1147007 [Yersinia enterocolitica]
MARRIQRLNIWMNGQHVGYWEKNRGEESLVYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSRDKSWIVRLPQEDMCQATGTSPLKKYQMDGGPSITTIMEILSGSDNASEDRNVFFKAQIIFWLLAATDGHAKNFS
IAHLPGSRYHLTPLYDVLSTHPIIGSGRNQIAIQKSKLAMAVRGSKNYYLINQIQRRHWRKQAEFVGLGAIQADTIIDEI
IAATPRVITQVQAQLPANFPADLAEKILTGLHKQCEKISAML

Nucleotide

• Length: 1329 bp

>T186721 NZ_CP089765:2404512-2404796 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11155.81 Da
• Isoelectric Point: 8.5374

>AT186721 WP_020282668.1 NZ_CP068147:1145378-1145677 [Yersinia enterocolitica]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPTSASVERLFKVLQLLDVELILTEKKNASAHPNK
THQPEQSQTIDLPSKQEDW

Nucleotide

• Length: 300 bp

>AT186721 NZ_CP089765:2404280-2404522 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA