Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4185191..4186151 Replicon chromosome
Accession NZ_CP068146
Organism Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)


Gene name - Uniprot ID A0A7U7FM81
Locus tag I6I39_RS18675 Protein ID WP_013649871.1
Coordinates 4185693..4186151 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7U7FM48
Locus tag I6I39_RS18670 Protein ID WP_013649872.1
Coordinates 4185191..4185637 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I39_RS18650 4180716..4181423 + 708 WP_005160995.1 murein tripeptide amidase MpaA -
I6I39_RS18655 4181420..4182391 - 972 WP_050124345.1 L-Ala-D/L-Glu epimerase -
I6I39_RS18660 4182544..4183047 + 504 WP_005161000.1 thiol peroxidase -
I6I39_RS18665 4183294..4184871 - 1578 WP_005161002.1 transcriptional regulator TyrR -
I6I39_RS18670 4185191..4185637 + 447 WP_013649872.1 DUF2384 domain-containing protein Antitoxin
I6I39_RS18675 4185693..4186151 + 459 WP_013649871.1 RES family NAD+ phosphorylase Toxin
I6I39_RS18680 4186154..4187218 - 1065 WP_005161009.1 YcjF family protein -
I6I39_RS18685 4187215..4188612 - 1398 WP_005161012.1 YcjX family protein -
I6I39_RS18690 4188593..4188832 - 240 WP_005161016.1 phage shock protein PspD -
I6I39_RS18695 4188878..4189282 - 405 WP_005161018.1 envelope stress response membrane protein PspC -
I6I39_RS18700 4189282..4189509 - 228 WP_005161022.1 envelope stress response membrane protein PspB -
I6I39_RS18705 4189671..4190336 - 666 WP_005161029.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17158.54 Da        Isoelectric Point: 4.6717

>T186718 WP_013649871.1 NZ_CP068146:4185693-4186151 [Yersinia enterocolitica]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Download         Length: 459 bp

>T186718 NZ_CP089765:c1534788-1534420 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16322.77 Da        Isoelectric Point: 9.8753

>AT186718 WP_013649872.1 NZ_CP068146:4185191-4185637 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Download         Length: 447 bp

>AT186718 NZ_CP089765:c1535006-1534785 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FM81

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FM48

References