Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3078519..3079137 Replicon chromosome
Accession NZ_CP068146
Organism Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag I6I39_RS13570 Protein ID WP_002208622.1
Coordinates 3078519..3078722 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag I6I39_RS13575 Protein ID WP_005163463.1
Coordinates 3078769..3079137 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I39_RS13540 3073890..3074228 + 339 WP_002208627.1 P-II family nitrogen regulator -
I6I39_RS13545 3074268..3075557 + 1290 WP_005167660.1 ammonium transporter AmtB -
I6I39_RS13550 3075671..3076534 - 864 WP_005163474.1 acyl-CoA thioesterase II -
I6I39_RS13555 3076795..3077325 + 531 WP_050124406.1 YbaY family lipoprotein -
I6I39_RS13560 3077377..3077682 - 306 WP_005163466.1 MGMT family protein -
I6I39_RS13570 3078519..3078722 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
I6I39_RS13575 3078769..3079137 - 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
I6I39_RS13580 3079295..3079648 - 354 WP_005163460.1 hypothetical protein -
I6I39_RS13585 3080414..3081124 + 711 WP_172668375.1 ABC transporter ATP-binding protein -
I6I39_RS13590 3081138..3081995 + 858 WP_005163445.1 metal ABC transporter permease -
I6I39_RS13595 3082058..3082936 + 879 WP_005163442.1 metal ABC transporter substrate-binding protein -
I6I39_RS13600 3083064..3083207 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
I6I39_RS13605 3083223..3083483 - 261 WP_005163438.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T186709 WP_002208622.1 NZ_CP068146:c3078722-3078519 [Yersinia enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T186709 NZ_CP089762:c4307364-4306447 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT186709 WP_005163463.1 NZ_CP068146:c3079137-3078769 [Yersinia enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT186709 NZ_CP089762:c4308128-4307370 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References