Detailed information of TA system TA186707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2346549..2348178
• Replicon: chromosome
• Accession: NZ_CP068146
• Organism: Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U7IQ60
• Locus tag: I6I39_RS10255
• Protein ID: WP_005165219.1
• Coordinates: 2346549..2347877 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A7U7FJW4
• Locus tag: I6I39_RS10260
• Protein ID: WP_005165217.1
• Coordinates: 2347879..2348178 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I39_RS10240	2342140..2342493	+	354	WP_005165225.1	MmcQ/YjbR family DNA-binding protein	-
I6I39_RS10245	2342552..2345383	-	2832	WP_005165223.1	excinuclease ABC subunit UvrA	-
I6I39_RS10250	2345912..2346460	+	549	WP_005165221.1	single-stranded DNA-binding protein SSB1	-
I6I39_RS10255	2346549..2347877	-	1329	WP_005165219.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6I39_RS10260	2347879..2348178	-	300	WP_005165217.1	helix-turn-helix transcriptional regulator	Antitoxin
I6I39_RS10265	2348473..2349144	+	672	WP_005165214.1	glutathione S-transferase	-
I6I39_RS10270	2349505..2350872	+	1368	WP_005165212.1	NCS2 family permease	-
I6I39_RS10275	2351087..2352736	+	1650	WP_005165210.1	Na+/H+ antiporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49925.93 Da
• Isoelectric Point: 6.8736

>T186707 WP_005165219.1 NZ_CP068146:c2347877-2346549 [Yersinia enterocolitica]
MARRIQRLNIWMNGQHVGYWEKNRGEESLVYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSRDKSWIVRLPQEDMCQATGTSPLKKYQMDGGPSITTIMEILSGSDNASEDRNVFFKAQIIFWLLAATDGHAKNFS
IAHLPGSRYHLTPLYDVLSTHPIIGSGRNQIAVQKSKLAMAVRGSKNYYLINQIQRRHWRKQAEFVGLGAIQADTIIDEI
IAATPRVITQVQAQLPANFPADLAEKILTGLHKQCEKISAML

Nucleotide

• Length: 1329 bp

>T186707 NZ_CP089762:c4044828-4044295 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11141.78 Da
• Isoelectric Point: 8.5374

>AT186707 WP_005165217.1 NZ_CP068146:c2348178-2347879 [Yersinia enterocolitica]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPTSASVERLFKVLQLLDVELILSEKKNASAHPNK
THQPEQSQTIDLPSKQEDW

Nucleotide

• Length: 300 bp

>AT186707 NZ_CP089762:c4045105-4044839 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A7U7IQ60

Antitoxin

• AlphaFold DB: A0A7U7FJW4