Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1977736..1978379 Replicon chromosome
Accession NZ_CP068146
Organism Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag I6I39_RS08680 Protein ID WP_005161957.1
Coordinates 1977960..1978379 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag I6I39_RS08675 Protein ID WP_005161959.1
Coordinates 1977736..1977963 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I39_RS08650 1972849..1974012 + 1164 WP_005161974.1 mannitol-1-phosphate 5-dehydrogenase -
I6I39_RS08655 1974244..1974798 + 555 WP_005161972.1 MltR family transcriptional regulator -
I6I39_RS08660 1974795..1975406 - 612 WP_016266331.1 LysE family translocator -
I6I39_RS08665 1975674..1977155 + 1482 WP_005161967.1 PLP-dependent aminotransferase family protein -
I6I39_RS08670 1977248..1977604 + 357 WP_005161962.1 YibL family ribosome-associated protein -
I6I39_RS08675 1977736..1977963 + 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6I39_RS08680 1977960..1978379 + 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
I6I39_RS08685 1978533..1979204 - 672 WP_050124137.1 6-N-hydroxylaminopurine resistance protein -
I6I39_RS08690 1979283..1981232 - 1950 WP_005161951.1 methyl-accepting chemotaxis protein -
I6I39_RS08695 1981556..1982179 - 624 WP_013650637.1 superoxide dismutase [Mn] -
I6I39_RS08700 1982306..1983160 - 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T186705 WP_005161957.1 NZ_CP068146:1977960-1978379 [Yersinia enterocolitica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

>T186705 NZ_CP089762:c2035151-2033829 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT186705 WP_005161959.1 NZ_CP068146:1977736-1977963 [Yersinia enterocolitica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT186705 NZ_CP089762:c2035417-2035151 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References