Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1290653..1291188 Replicon chromosome
Accession NZ_CP068146
Organism Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7FI46
Locus tag I6I39_RS05590 Protein ID WP_005156226.1
Coordinates 1290653..1290940 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag I6I39_RS05595 Protein ID WP_005156229.1
Coordinates 1290937..1291188 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I39_RS05560 1285912..1286718 + 807 WP_005156209.1 phosphonate C-P lyase system protein PhnK -
I6I39_RS05565 1286732..1287466 + 735 WP_005156211.1 phosphonate C-P lyase system protein PhnL -
I6I39_RS05570 1287463..1288611 + 1149 WP_005156213.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
I6I39_RS05575 1288611..1289189 + 579 Protein_1089 ribose 1,5-bisphosphokinase -
I6I39_RS05580 1289180..1289947 + 768 WP_005156220.1 phosphonate metabolism protein PhnP -
I6I39_RS05585 1289948..1290577 - 630 WP_005175332.1 hypothetical protein -
I6I39_RS05590 1290653..1290940 - 288 WP_005156226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I39_RS05595 1290937..1291188 - 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6I39_RS05600 1291396..1291848 - 453 WP_005181269.1 YhbP family protein -
I6I39_RS05605 1291922..1293088 - 1167 WP_005156235.1 alginate lyase family protein -
I6I39_RS05610 1293102..1294217 - 1116 WP_005156237.1 ABC transporter ATP-binding protein -
I6I39_RS05615 1294229..1295068 - 840 WP_005156238.1 carbohydrate ABC transporter permease -
I6I39_RS05620 1295087..1295971 - 885 WP_005156239.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11002.07 Da        Isoelectric Point: 10.3544

>T186703 WP_005156226.1 NZ_CP068146:c1290940-1290653 [Yersinia enterocolitica]
MIYKVKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T186703 NZ_CP089762:41307-41714 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT186703 WP_005156229.1 NZ_CP068146:c1291188-1290937 [Yersinia enterocolitica]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT186703 NZ_CP089762:41060-41326 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FI46

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References