Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1254949..1255476 Replicon chromosome
Accession NZ_CP068146
Organism Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)


Gene name relE Uniprot ID A0A7T9XW08
Locus tag I6I39_RS05410 Protein ID WP_005166250.1
Coordinates 1254949..1255224 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7T9XW39
Locus tag I6I39_RS05415 Protein ID WP_005166251.1
Coordinates 1255228..1255476 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I39_RS05385 1250397..1251287 - 891 Protein_1052 DNA helicase -
I6I39_RS05390 1251409..1252917 + 1509 WP_005180650.1 IS21-like element ISYen2A family transposase -
I6I39_RS05395 1252904..1253629 + 726 WP_005180647.1 IS21-like element ISYen2A/ISYen2B family helper ATPase IstB -
I6I39_RS05400 1253683..1253814 - 132 Protein_1055 IS3 family transposase -
I6I39_RS05405 1254042..1254830 - 789 WP_005166249.1 helix-turn-helix domain-containing protein -
I6I39_RS05410 1254949..1255224 - 276 WP_005166250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I39_RS05415 1255228..1255476 - 249 WP_005166251.1 ribbon-helix-helix domain-containing protein Antitoxin
I6I39_RS05420 1255553..1255846 - 294 Protein_1059 DUF4942 domain-containing protein -
I6I39_RS05425 1255907..1256416 + 510 Protein_1060 helix-turn-helix domain containing protein -
I6I39_RS05435 1256713..1257783 - 1071 WP_005166254.1 LPS export ABC transporter permease LptG -
I6I39_RS05440 1257783..1258877 - 1095 WP_005166255.1 LPS export ABC transporter permease LptF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10974.31 Da        Isoelectric Point: 4.5486

>T186702 WP_005166250.1 NZ_CP068146:c1255224-1254949 [Yersinia enterocolitica]
MEIYWTLKAQDDLERIYCFALQYSRQHGDDVLDRLITGCAGLTAYPAIGVQQTRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Download         Length: 276 bp

>T186702 NZ_CP089745:c5328634-5328356 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9034.30 Da        Isoelectric Point: 6.4624

>AT186702 WP_005166251.1 NZ_CP068146:c1255476-1255228 [Yersinia enterocolitica]
MGSLTKQTISAQIPVELATAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
QS

Download         Length: 249 bp

>AT186702 NZ_CP089745:c5328344-5328039 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9XW08

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9XW39

References