Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 946146..946818 Replicon chromosome
Accession NZ_CP068146
Organism Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag I6I39_RS04170 Protein ID WP_005166047.1
Coordinates 946146..946571 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag I6I39_RS04175 Protein ID WP_004390965.1
Coordinates 946552..946818 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I39_RS04150 941925..942443 + 519 WP_005166042.1 flavodoxin FldB -
I6I39_RS04155 942502..943923 - 1422 WP_005166043.1 cell envelope integrity protein CreD -
I6I39_RS04160 944015..945437 - 1423 Protein_810 two-component system sensor histidine kinase CreC -
I6I39_RS04165 945448..946146 - 699 WP_005166045.1 two-component system response regulator CreB -
I6I39_RS04170 946146..946571 - 426 WP_005166047.1 protein YgfX Toxin
I6I39_RS04175 946552..946818 - 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
I6I39_RS04180 947085..948077 + 993 WP_005166051.1 tRNA-modifying protein YgfZ -
I6I39_RS04185 948273..949275 + 1003 Protein_815 IS110 family transposase -
I6I39_RS04190 949687..950370 - 684 WP_005180855.1 hemolysin III family protein -
I6I39_RS04195 950601..951203 + 603 WP_005164134.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T186701 WP_005166047.1 NZ_CP068146:c946571-946146 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

>T186701 NZ_CP089745:c4703242-4702877 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGATCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT186701 WP_004390965.1 NZ_CP068146:c946818-946552 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT186701 NZ_CP089745:c4702884-4702561 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGGACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAAATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAACTGGAAGTGATTGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References