Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1443613..1444239 Replicon chromosome
Accession NZ_CP068145
Organism Morganella morganii strain FDAARGOS_1085

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag I6I42_RS06575 Protein ID WP_024474604.1
Coordinates 1443613..1443816 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag I6I42_RS06580 Protein ID WP_004236473.1
Coordinates 1443880..1444239 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I42_RS06555 1440171..1440509 + 339 WP_004236467.1 P-II family nitrogen regulator -
I6I42_RS06560 1440529..1441818 + 1290 WP_024474602.1 ammonium transporter AmtB -
I6I42_RS06565 1441878..1442741 - 864 WP_024474603.1 acyl-CoA thioesterase II -
I6I42_RS06575 1443613..1443816 - 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
I6I42_RS06580 1443880..1444239 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
I6I42_RS06585 1444802..1447978 - 3177 WP_024474605.1 efflux RND transporter permease subunit -
I6I42_RS06590 1447993..1449189 - 1197 WP_024474606.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T186697 WP_024474604.1 NZ_CP068145:c1443816-1443613 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T186697 NZ_CP089745:c137449-137168 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAAGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT186697 WP_004236473.1 NZ_CP068145:c1444239-1443880 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT186697 NZ_CP089745:c137673-137446 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References