Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 917017..917492 Replicon chromosome
Accession NZ_CP068145
Organism Morganella morganii strain FDAARGOS_1085

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag I6I42_RS04295 Protein ID WP_201893727.1
Coordinates 917394..917492 (+) Length 33 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6I42_RS04290 Protein ID WP_126027761.1
Coordinates 917017..917373 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I42_RS04255 913051..913767 + 717 WP_141438678.1 WYL domain-containing protein -
I6I42_RS04260 913803..914255 + 453 WP_201893719.1 hypothetical protein -
I6I42_RS04265 914327..914800 + 474 WP_201893721.1 hypothetical protein -
I6I42_RS04270 914920..915741 + 822 WP_201893723.1 DUF945 domain-containing protein -
I6I42_RS04275 915772..916215 + 444 WP_200782540.1 antirestriction protein -
I6I42_RS04280 916228..916773 + 546 WP_201893725.1 DNA repair protein RadC -
I6I42_RS04285 916770..916991 + 222 WP_058781956.1 DUF987 domain-containing protein -
I6I42_RS04290 917017..917373 + 357 WP_126027761.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6I42_RS04295 917394..917492 + 99 WP_201893727.1 TA system toxin CbtA family protein Toxin
I6I42_RS04300 917784..919049 + 1266 WP_201893730.1 hypothetical protein -
I6I42_RS04305 919248..919850 + 603 WP_201893743.1 tyrosine-type recombinase/integrase -
I6I42_RS04310 920232..921623 - 1392 WP_201893744.1 DUF2971 domain-containing protein -
I6I42_RS04315 921758..922391 + 634 Protein_817 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 903117..930553 27436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-30)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 33 a.a.        Molecular weight: 3537.39 Da        Isoelectric Point: 10.7884

>T186696 WP_201893727.1 NZ_CP068145:917394-917492 [Morganella morganii]
MKFLPATTLRAAKSCPTPVAIWQMLLTHLLLA

Download         Length: 99 bp

>T186696 NZ_CP089743:c4916986-4916636 [Bacillus paranthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13179.05 Da        Isoelectric Point: 7.6671

>AT186696 WP_126027761.1 NZ_CP068145:917017-917373 [Morganella morganii]
MNNHSESGSKPENPVCPQWGLKRSITPCFGARLVQEGNRLHFLADRAGFNGAFSNNDALRLDQAFPLMLKQLELMLFSGK
LNPRYQHCVTLYHNGLTCEADTLGSCGYVYIAVYPTQL

Download         Length: 357 bp

>AT186696 NZ_CP089743:c4917278-4916991 [Bacillus paranthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References