Detailed information of TA system TA186695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 306402..307219
• Replicon: chromosome
• Accession: NZ_CP068145
• Organism: Morganella morganii strain FDAARGOS_1085

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: I6I42_RS01465
• Protein ID: WP_201894219.1
• Coordinates: 306402..306884 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: I6I42_RS01470
• Protein ID: WP_201893569.1
• Coordinates: 306911..307219 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I42_RS01435	301766..302389	-	624	WP_024473603.1	thiol:disulfide interchange protein DsbA	-
I6I42_RS01440	302408..303403	-	996	WP_024473604.1	serine/threonine protein kinase	-
I6I42_RS01445	303403..303672	-	270	WP_004240741.1	YihD family protein	-
I6I42_RS01450	303875..304990	+	1116	WP_201893568.1	molybdenum cofactor guanylyltransferase MobA	-
I6I42_RS01455	305200..305502	+	303	WP_004240743.1	exported protein precursor	-
I6I42_RS01460	305630..306151	+	522	WP_024473606.1	isopentenyl-diphosphate Delta-isomerase	-
I6I42_RS01465	306402..306884	-	483	WP_201894219.1	GNAT family N-acetyltransferase	Toxin
I6I42_RS01470	306911..307219	-	309	WP_201893569.1	DUF1778 domain-containing protein	Antitoxin
I6I42_RS01475	307352..308704	-	1353	WP_024473609.1	glutathione-disulfide reductase	-
I6I42_RS01480	308774..309616	-	843	WP_024473610.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
I6I42_RS01485	309806..310195	+	390	WP_004236536.1	DUF1090 domain-containing protein	-
I6I42_RS01490	310586..311578	+	993	WP_024473611.1	inner membrane protein YhjD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (34-135)

Antitoxin

• Vibrio phage ICP1, Orf50 (17-102)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17811.66 Da
• Isoelectric Point: 10.0986

>T186695 WP_201894219.1 NZ_CP068145:c306884-306402 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRIFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILLGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEYTGFMPSPADPMLLMITLRDLQLVTGIYSE

Nucleotide

• Length: 483 bp

>T186695 NZ_CP089743:c2771737-2771000 [Bacillus paranthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGGGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACTATGATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11526.18 Da
• Isoelectric Point: 9.8096

>AT186695 WP_201893569.1 NZ_CP068145:c307219-306911 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLANLRVIDVSTDVYQQFITRL
DMAPQSGEALRKTMLTKAPWEK

Nucleotide

• Length: 309 bp

>AT186695 NZ_CP089743:c2770887-2770762 [Bacillus paranthracis]
GTGATAAAAAATAGTGACAATGATTTTTTTAAAGAAGACAATGAAGATACAACGGATTTCTCGTTAATTAAAGGGGATAC
GATGCAGCAAGTAGAAGAGTTAGAAGAAGAATTGAAAAGAAAATGA