Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1937897..1938374 Replicon chromosome
Accession NZ_CP068143
Organism Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag I6I43_RS09680 Protein ID WP_000052076.1
Coordinates 1938186..1938374 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag I6I43_RS09675 Protein ID WP_001059690.1
Coordinates 1937897..1938157 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I43_RS09640 1933290..1934006 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
I6I43_RS09645 1934154..1934576 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
I6I43_RS09650 1934975..1935469 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
I6I43_RS09655 1935624..1936241 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
I6I43_RS09660 1936314..1936895 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
I6I43_RS09665 1937120..1937356 + 237 WP_000368687.1 hypothetical protein -
I6I43_RS09670 1937353..1937556 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
I6I43_RS09675 1937897..1938157 + 261 WP_001059690.1 hypothetical protein Antitoxin
I6I43_RS09680 1938186..1938374 + 189 WP_000052076.1 hypothetical protein Toxin
I6I43_RS09685 1938562..1939131 + 570 WP_045178121.1 orthopoxovirus protein, PF05708 family -
I6I43_RS09690 1939219..1939503 + 285 WP_001004401.1 hypothetical protein -
I6I43_RS09695 1939565..1939783 + 219 WP_000005886.1 hypothetical protein -
I6I43_RS09700 1940279..1940479 - 201 WP_001059082.1 cold-shock protein -
I6I43_RS09705 1940836..1941522 - 687 WP_001566557.1 thermonuclease family protein -
I6I43_RS09710 1941863..1942333 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T186694 WP_000052076.1 NZ_CP068143:1938186-1938374 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T186694 NZ_CP089742:3592691-3592972 [Melaminivora jejuensis]
ATGGCCGTCGTTTCATTCCAATGTCCAGACACCCAGCGGCTGTTCACCAGCGGCAAGACGCGCCGCTTCGCCAATATCCA
GGCGGTGGCGGAGCGCAAACTGGTGCAACGGGACGCGGCGGCCACACTGGACTTCCTGCGTAGCCCGCCGGGCAACCGGT
TGGAGGCGCTGACCGGCGATCGCCAGGGGCAGCACAGCATTCGCATCAATGCCCAGTGGCGTGTATGTTTTGTCTGGATG
GACGAGGGGCCTGCCCAGGTGGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT186694 WP_001059690.1 NZ_CP068143:1937897-1938157 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT186694 NZ_CP089742:3593003-3593314 [Melaminivora jejuensis]
ATGTTCAAGAACGGTATGCGCCCCGTACATCCTGGCGAAGTACTGCGTGAGGATTACCTCAAGCCGCTGGCGCTGAGCGC
CAACGCGCTGGCCCGGCAGTTGCGCGTGCCGGCATCGCGCATCAATGACATCGTGCTGGGGCGCCGGGGTATCACTGCCG
ATACGGCACTGCGTCTATGCCGTTTTTTTGGCGGCGATCCACAGTCGTGGCTGAACCTGCAGACGGCCTATGACTTGCGT
ATGGCGCAGATGGATGAAGCACTGCAGCAGGCCGTGCTGGCAGTGCAGCCCATGCAACTGCACCCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References