Detailed information of TA system TA186691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 875031..875807
• Replicon: chromosome
• Accession: NZ_CP068143
• Organism: Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: I6I43_RS04585
• Protein ID: WP_000031108.1
• Coordinates: 875655..875807 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: I6I43_RS04580
• Protein ID: WP_001251224.1
• Coordinates: 875031..875630 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I43_RS04560	870947..872404	+	1458	WP_000649907.1	ABC transporter permease subunit	-
I6I43_RS04565	872397..873119	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
I6I43_RS04570	873270..874397	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6I43_RS04575	874402..874872	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6I43_RS04580	875031..875630	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
I6I43_RS04585	875655..875807	+	153	WP_000031108.1	hypothetical protein	Toxin
I6I43_RS04590	876410..876805	+	396	WP_000901023.1	hypothetical protein	-
I6I43_RS04595	877001..878386	+	1386	WP_000116229.1	class II fumarate hydratase	-
I6I43_RS04600	878849..879670	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T186691 WP_000031108.1 NZ_CP068143:875655-875807 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T186691 NZ_CP089742:c2641362-2641111 [Melaminivora jejuensis]
ATGGATGCCATCACTTACTCTGCTGCCCGGGCCAATCTGGCGGCCACCATGGATCGCGTCTGCGATGACAGCGAGCCCAT
CATCATTACCCGCAGCGGCCAGCGGTCGGTGGTCATGCTGTCGCTGGAGGATTACAACGCACTGGAAGAAACTGCCTATT
TGCTGCGCAGCCCGAAAAATGCCAAACGGCTGATGGACGCGATCGCTGAGCTGGAATCATGCAAGGGCCGTGAGCAGGCG
CTGATCGAATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT186691 WP_001251224.1 NZ_CP068143:875031-875630 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT186691 NZ_CP089742:c2641114-2640860 [Melaminivora jejuensis]
ATGAAGCTGGTTTTTGCCGAACAGGCCTGGCAAGACTATCTGTACTGGCAGGAGAACGACAAAAAGCTGGTGCAGAGGAT
CAATGCTCTCATCAGGGAAACCAGCCGCACGCCATTTCAGGGGACGGGCAAGCCCGAACCCCTGAAGCACGCATTTTCAG
GCTATTGCTCTCGGCGCATCACCGGCGAGCACCGGATGGTCTACAAGGCGAGTGAGGGGGAGCTGCTGATTGCCCAGCTG
CGCTACCACTACTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4