Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 656308..656822 Replicon chromosome
Accession NZ_CP068143
Organism Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag I6I43_RS03245 Protein ID WP_000581792.1
Coordinates 656613..656822 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag I6I43_RS03240 Protein ID WP_000138932.1
Coordinates 656308..656601 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I43_RS03220 651918..652559 + 642 WP_000483164.1 thiamine phosphate synthase -
I6I43_RS03225 652645..653517 + 873 WP_000725802.1 membrane protein insertase YidC -
I6I43_RS03230 653983..654630 - 648 WP_001187630.1 HD domain-containing protein -
I6I43_RS03235 654658..656142 - 1485 WP_000571549.1 cardiolipin synthase -
I6I43_RS03240 656308..656601 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6I43_RS03245 656613..656822 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
I6I43_RS03250 656950..657087 + 138 WP_000828354.1 hypothetical protein -
I6I43_RS03255 657351..658553 - 1203 WP_001109939.1 rod shape-determining protein RodA -
I6I43_RS03260 658871..659941 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
I6I43_RS03265 659956..661314 + 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T186685 WP_000581792.1 NZ_CP068143:656613-656822 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T186685 NZ_CP089742:1626276-1626485 [Melaminivora jejuensis]
GTGGCTGGAGCCTTCGAGGATGCCGACTACACAGTCATCGTCCGGCGTGACGCGCCCGATGCCGTGGTCATGTCTCTGGA
CACTTTCAACAGCCTGATGGAGACCGTGCACCTGCTCAAGTCGCCCGCCAACGCCACCCATCTGGCGCGCTCGATCGCCC
AGTTGCGCGCAGGCCAGGTGCAGGAGCGGGATCTGGCAGATGCCGATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT186685 WP_000138932.1 NZ_CP068143:656308-656601 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT186685 NZ_CP089742:1626475-1626762 [Melaminivora jejuensis]
ATGCCGATTGAGTCGCCAGCAGACAGGCTGGTGCGGCTGACCTGGACGCAGGCGGCCTGGGACGACTACGCCTATTGGCA
GGGCCAGGACAAAAAAACCCTGAAACGCATCAACCTGCTGATCCAGGATTGCCTGCGCCAACCGCTTTCCGGCATCGGCA
AACCTGAGCCGCTGAAAGAAAACCTGTATGGCTTTTGGTCACGGCGCATCGACGATACGAACAGGCTGGTGTATTGCGTG
GACGGGCAGGCGTTGGTGGTGATCGCCTGCCGCTATCACTATCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References