Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3470237..3470894 Replicon chromosome
Accession NZ_CP068139
Organism Klebsiella pneumoniae strain FDAARGOS_1076

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6I33_RS16825 Protein ID WP_002916310.1
Coordinates 3470484..3470894 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6I33_RS16820 Protein ID WP_002916312.1
Coordinates 3470237..3470503 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I33_RS16795 3465393..3466826 - 1434 WP_004174453.1 6-phospho-beta-glucosidase -
I6I33_RS16800 3466945..3467673 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6I33_RS16805 3467723..3468034 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6I33_RS16810 3468198..3468857 + 660 WP_004174454.1 hemolysin III family protein -
I6I33_RS16815 3469008..3469991 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I6I33_RS16820 3470237..3470503 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6I33_RS16825 3470484..3470894 + 411 WP_002916310.1 protein YgfX Toxin
I6I33_RS16830 3470901..3471422 - 522 WP_002916308.1 flavodoxin FldB -
I6I33_RS16835 3471523..3472419 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6I33_RS16840 3472442..3473155 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6I33_RS16845 3473161..3474894 + 1734 WP_046623736.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T186666 WP_002916310.1 NZ_CP068139:3470484-3470894 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T186666 NZ_CP089611:2795550-2795975 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACCGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT186666 WP_002916312.1 NZ_CP068139:3470237-3470503 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186666 NZ_CP089611:2795323-2795544 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References