Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1175657..1176186 Replicon chromosome
Accession NZ_CP068136
Organism Staphylococcus epidermidis strain FDAARGOS_1083

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag I6I40_RS05505 Protein ID WP_001829891.1
Coordinates 1175824..1176186 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag I6I40_RS05500 Protein ID WP_001829931.1
Coordinates 1175657..1175827 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I40_RS05475 1171481..1171960 + 480 WP_010959254.1 PH domain-containing protein -
I6I40_RS05480 1171953..1173458 + 1506 WP_002457110.1 PH domain-containing protein -
I6I40_RS05485 1173445..1173954 + 510 WP_077755959.1 PH domain-containing protein -
I6I40_RS05490 1174002..1174355 + 354 WP_002457108.1 holo-ACP synthase -
I6I40_RS05495 1174422..1175570 + 1149 WP_002457107.1 alanine racemase -
I6I40_RS05500 1175657..1175827 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6I40_RS05505 1175824..1176186 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6I40_RS05510 1176531..1177532 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
I6I40_RS05515 1177632..1177958 + 327 WP_001829952.1 anti-sigma factor antagonist -
I6I40_RS05520 1177960..1178439 + 480 WP_001829903.1 anti-sigma B factor RsbW -
I6I40_RS05525 1178414..1179184 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T186657 WP_001829891.1 NZ_CP068136:1175824-1176186 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T186657 NZ_CP089611:2202884-2203261 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT186657 WP_001829931.1 NZ_CP068136:1175657-1175827 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT186657 NZ_CP089611:2203303-2203752 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References