Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1164472..1164981 Replicon chromosome
Accession NZ_CP068136
Organism Staphylococcus epidermidis strain FDAARGOS_1083

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag I6I40_RS05445 Protein ID WP_001829980.1
Coordinates 1164772..1164981 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag I6I40_RS05440 Protein ID WP_001829893.1
Coordinates 1164472..1164765 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I40_RS05415 1159480..1160268 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
I6I40_RS05420 1160274..1160912 + 639 WP_002505076.1 thiamine phosphate synthase -
I6I40_RS05425 1161001..1161873 + 873 WP_002458703.1 membrane protein insertase YidC -
I6I40_RS05430 1161979..1162632 - 654 WP_001829983.1 HD domain-containing protein -
I6I40_RS05435 1162814..1164298 - 1485 WP_002457116.1 cardiolipin synthase -
I6I40_RS05440 1164472..1164765 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6I40_RS05445 1164772..1164981 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
I6I40_RS05450 1165124..1165261 + 138 WP_001829949.1 hypothetical protein -
I6I40_RS05455 1165360..1166571 - 1212 WP_002486299.1 rod shape-determining protein RodA -
I6I40_RS05460 1166962..1168035 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
I6I40_RS05465 1168047..1169402 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T186656 WP_001829980.1 NZ_CP068136:1164772-1164981 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T186656 NZ_CP089611:c2196138-2195809 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT186656 WP_001829893.1 NZ_CP068136:1164472-1164765 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT186656 NZ_CP089611:c2196512-2196135 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References