Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1119292..1119863 Replicon chromosome
Accession NZ_CP068122
Organism Enterococcus hirae strain FDAARGOS_1124

Toxin (Protein)


Gene name mazF Uniprot ID I6SW09
Locus tag I6I81_RS05820 Protein ID WP_010738536.1
Coordinates 1119522..1119863 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I6T4M0
Locus tag I6I81_RS05815 Protein ID WP_010738535.1
Coordinates 1119292..1119522 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I81_RS05805 1116307..1117272 + 966 WP_034866085.1 helix-turn-helix domain-containing protein -
I6I81_RS05810 1117453..1118832 - 1380 WP_010738534.1 FAD-dependent oxidoreductase -
I6I81_RS05815 1119292..1119522 + 231 WP_010738535.1 hypothetical protein Antitoxin
I6I81_RS05820 1119522..1119863 + 342 WP_010738536.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6I81_RS05825 1120027..1121193 - 1167 WP_010738537.1 pyridoxal phosphate-dependent aminotransferase -
I6I81_RS05830 1121223..1122332 - 1110 WP_025480561.1 amidohydrolase -
I6I81_RS05835 1122292..1123641 - 1350 WP_010720195.1 aspartate kinase -
I6I81_RS05840 1123638..1124639 - 1002 WP_034866081.1 aspartate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13101.46 Da        Isoelectric Point: 10.1962

>T186650 WP_010738536.1 NZ_CP068122:1119522-1119863 [Enterococcus hirae]
VPKARNYIPKKGDIVWIDFDPSTGKEIQKRRPGLVVSRYEFNCTTMFAIICPITSTIKNLPTRYSLPKDLDTKGQVLISQ
LKSLDFKERKLKKVENLPLQDMAKIDQIIQYIF

Download         Length: 342 bp

>T186650 NZ_CP089611:1540344-1541165 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8577.57 Da        Isoelectric Point: 4.1196

>AT186650 WP_010738535.1 NZ_CP068122:1119292-1119522 [Enterococcus hirae]
MLITKSRLQGSSVVITLPSDNGKKPSENQEYIVVYSEDGTITLVPKIEDPFSAGQEAEYYEKDEWKDLTPEGREIL

Download         Length: 231 bp

>AT186650 NZ_CP089611:1541158-1541394 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DJ27

Antitoxin

Source ID Structure
AlphaFold DB A0A449E900

References