Detailed information of TA system TA186644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 286371..286878
• Replicon: chromosome
• Accession: NZ_CP068114
• Organism: Fusobacterium canifelinum strain FDAARGOS_1126

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6I83_RS01365
• Protein ID: WP_201627329.1
• Coordinates: 286618..286878 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: I6I83_RS01360
• Protein ID: WP_005892688.1
• Coordinates: 286371..286625 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I83_RS01345	283169..283537	+	369	WP_201627327.1	arsenate reductase family protein	-
I6I83_RS01350	283569..284843	+	1275	WP_201627328.1	branched-chain amino acid transport system II carrier protein	-
I6I83_RS01355	284869..286077	+	1209	WP_147367412.1	tyrosine--tRNA ligase	-
I6I83_RS01360	286371..286625	+	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6I83_RS01365	286618..286878	+	261	WP_201627329.1	Txe/YoeB family addiction module toxin	Toxin
I6I83_RS01370	286888..287391	+	504	WP_201627330.1	GNAT family N-acetyltransferase	-
I6I83_RS01375	287419..287907	+	489	WP_201627920.1	GNAT family N-acetyltransferase	-
I6I83_RS01380	287904..288563	+	660	WP_201627331.1	endonuclease III	-
I6I83_RS01385	288632..289825	+	1194	WP_201627332.1	cysteine desulfurase	-
I6I83_RS01390	289889..290266	+	378	WP_124796962.1	Fe-S cluster assembly scaffold protein NifU	-
I6I83_RS01395	290358..291641	+	1284	WP_201627333.1	D-alanyl-D-alanine carboxypeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10300.79 Da
• Isoelectric Point: 9.3654

>T186644 WP_201627329.1 NZ_CP068114:286618-286878 [Fusobacterium canifelinum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALNGIGKTEVLKNESAYSRRIDEKNRLVYRIVDGFIWIIAC
KGHYEE

Nucleotide

• Length: 261 bp

>T186644 NZ_CP089611:1018297-1018731 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT186644 WP_005892688.1 NZ_CP068114:286371-286625 [Fusobacterium canifelinum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT186644 NZ_CP089611:1018112-1018291 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3