Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 130296..130894 Replicon chromosome
Accession NZ_CP068112
Organism Mobiluncus curtisii strain FDAARGOS_1128

Toxin (Protein)


Gene name PumA Uniprot ID D6ZFY9
Locus tag I6I85_RS00695 Protein ID WP_013189226.1
Coordinates 130586..130894 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D6ZFZ0
Locus tag I6I85_RS00690 Protein ID WP_004009166.1
Coordinates 130296..130589 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I85_RS00650 125790..127010 + 1221 WP_013189234.1 phage major capsid protein -
I6I85_RS00655 127040..127357 + 318 WP_013189233.1 head-tail connector protein -
I6I85_RS00660 127373..127705 + 333 WP_041797999.1 head-tail adaptor protein -
I6I85_RS00665 127705..128142 + 438 WP_013189231.1 HK97 gp10 family phage protein -
I6I85_RS00670 128139..128483 + 345 WP_013189230.1 hypothetical protein -
I6I85_RS00675 128480..128992 - 513 WP_013189229.1 VanZ family protein -
I6I85_RS00680 129053..129664 + 612 WP_013189228.1 phage tail protein -
I6I85_RS00685 129686..130090 + 405 WP_013189227.1 hypothetical protein -
I6I85_RS00690 130296..130589 - 294 WP_004009166.1 putative addiction module antidote protein Antitoxin
I6I85_RS00695 130586..130894 - 309 WP_013189226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I85_RS00700 130947..133628 + 2682 WP_013189225.1 tape measure protein -
I6I85_RS00705 133633..134319 + 687 WP_013189224.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage tet(O) - 72127..153075 80948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-97)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11399.08 Da        Isoelectric Point: 9.8920

>T186642 WP_013189226.1 NZ_CP068112:c130894-130586 [Mobiluncus curtisii]
VEIISSSLFDAWLGELKDKHAQRRILHAIARCEAHGTMVGDIKPVGEKVNEMRFHFGPGYRVYYTQLGAVTVFLLAGGDK
SSQAKDIRTAQKLAQQVRKEQS

Download         Length: 309 bp

>T186642 NZ_CP089611:c760610-760173 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10642.17 Da        Isoelectric Point: 7.0095

>AT186642 WP_004009166.1 NZ_CP068112:c130589-130296 [Mobiluncus curtisii]
MKEVTFSAFDASKYLDSQEAMNDYLAIALEDGDTKTVQVVLRDIARAHGMSQLAKETQLNRESLYKSLSKDGNPSFAAIT
KIMKALGLKITLATQNA

Download         Length: 294 bp

>AT186642 NZ_CP089611:c760861-760607 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6UZ62

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1RCQ5

References