Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1404609..1405267 Replicon chromosome
Accession NZ_CP068103
Organism Peptoniphilus harei strain FDAARGOS_1136

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I6I93_RS06560 Protein ID WP_112889891.1
Coordinates 1404609..1404794 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6I93_RS06565 Protein ID WP_112889892.1
Coordinates 1404827..1405267 (+) Length 147 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I93_RS06530 1400869..1401039 + 171 WP_172605467.1 hypothetical protein -
I6I93_RS06535 1401082..1402371 - 1290 WP_112889889.1 hypothetical protein -
I6I93_RS06540 1402516..1403163 - 648 WP_112889890.1 PepSY domain-containing protein -
I6I93_RS06545 1403359..1404027 + 669 WP_070702311.1 GntR family transcriptional regulator -
I6I93_RS06555 1404306..1404464 + 159 WP_112890575.1 serine/threonine protein phosphatase -
I6I93_RS06560 1404609..1404794 + 186 WP_112889891.1 type II toxin-antitoxin system HicA family toxin Toxin
I6I93_RS06565 1404827..1405267 + 441 WP_112889892.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6I93_RS06570 1405606..1406436 + 831 WP_112889893.1 glutamate racemase -
I6I93_RS06575 1406455..1407237 - 783 WP_112889894.1 type III pantothenate kinase -
I6I93_RS06580 1407239..1407988 - 750 WP_112889895.1 ECF transporter S component -
I6I93_RS06585 1408038..1409000 - 963 WP_112889896.1 P1 family peptidase -
I6I93_RS06590 1409246..1409557 - 312 WP_112889897.1 MTH1187 family thiamine-binding protein -
I6I93_RS06595 1409567..1410214 - 648 WP_112889898.1 trimeric intracellular cation channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1387377..1405267 17890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-74)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6709.10 Da        Isoelectric Point: 10.8719

>T186640 WP_112889891.1 NZ_CP068103:1404609-1404794 [Peptoniphilus harei]
MPMTQDEMVKILKKNGFEVVKGGKGSHVKMTKPGLKRPIIIPHGELQKGTERGILKEAGLK

Download         Length: 186 bp

>T186640 NZ_CP089611:c759831-759523 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 147 a.a.        Molecular weight: 16284.38 Da        Isoelectric Point: 3.9713

>AT186640 WP_112889892.1 NZ_CP068103:1404827-1405267 [Peptoniphilus harei]
MLVSYPAIFYYSPEEKGYYVYMPDIEGAGTQGDSIEEALLMASDYLGIMAGSIIEGGDTLPKQSAISDLSIEDNFPFKDD
PEFDGFYDYSKSFISLVYVDLKDYLGSQELVKKTLSIPKWSNDLGNKLNLNFSKLLTEAIVNIAKN

Download         Length: 441 bp

>AT186640 NZ_CP089611:c760063-759818 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References