Detailed information of TA system TA186639

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii(toxin)
• Location: 521368..522793
• Replicon: chromosome
• Accession: NZ_CP068103
• Organism: Peptoniphilus harei strain FDAARGOS_1136

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: I6I93_RS02330
• Protein ID: WP_112890260.1
• Coordinates: 521368..522207 (-)
• Length: 280 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A233VYD1
• Locus tag: I6I93_RS02335
• Protein ID: WP_001109528.1
• Coordinates: 522200..522793 (-)
• Length: 198 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I93_RS02320	518924..519330	-	407	Protein_458	type III toxin-antitoxin system ToxN/AbiQ family toxin	-
I6I93_RS02325	519592..521298	-	1707	WP_070737662.1	DNA topoisomerase 3	-
I6I93_RS02330	521368..522207	-	840	WP_112890260.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6I93_RS02335	522200..522793	-	594	WP_001109528.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I6I93_RS02340	523098..523975	-	878	Protein_462	DUF4366 domain-containing protein	-
I6I93_RS02345	523991..526345	-	2355	WP_112890261.1	leucine-rich repeat protein	-
I6I93_RS02350	526342..526599	-	258	WP_072469619.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-259)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 280 a.a.
• Molecular weight: 32522.60 Da
• Isoelectric Point: 7.7852

>T186639 WP_112890260.1 NZ_CP068103:c522207-521368 [Peptoniphilus harei]
MNKAKLTAICHNISKESGLPFNSVMLYYFLESILKKLAQSKYHEKFIFKGGFLLSNVVGIDSRSTVDIDLLLRNMHLSEE
NVLKTIQELLEASHSDDISYKVNGISTIKEDDQYGGFRVSILCRMENIRQIVPLDIATGDVITPHPIDYKYISAFGQEDI
LIKAYPIETIVAEKIQTIYSRGFLNSRSKDYYDLYIIYKLKDKEIDTKILKEACIRTFDYRKTEFDIDKIINLMRMLKTD
QAFLYRWNSYSKKNLYARDIKFEDVIDNGINIIEKIKNQ

Nucleotide

• Length: 840 bp

>T186639 NZ_CP089611:c758205-757822 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 198 a.a.
• Molecular weight: 23592.27 Da
• Isoelectric Point: 9.2793

>AT186639 WP_001109528.1 NZ_CP068103:c522793-522200 [Peptoniphilus harei]
MNYRKQIEIHLKESGGIITSAYCRENNIPTVYLSRLAKEGKLFRVQKGIYIIEDGDFDEYYFFQYQYRKAIFSYETALFL
LGVTDKIPWRIDVTVYNGYKFNEKQDTLNINYVKKSIYNLGIIQKKTMFGNTVNVYSYERILCDFISNKEKMDTEVYVKL
IRSYFKYKDKDIHSLYKIARKMGIEDKVKEVMEVVYE

Nucleotide

• Length: 594 bp

>AT186639 NZ_CP089611:c758455-758300 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A233VYD1