Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 2210849..2211639 | Replicon | chromosome |
| Accession | NZ_CP068102 | ||
| Organism | Rothia aeria strain FDAARGOS_1137 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | I0UV63 |
| Locus tag | I6I94_RS09710 | Protein ID | WP_006887455.1 |
| Coordinates | 2210849..2211346 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | I0UV95 |
| Locus tag | I6I94_RS09715 | Protein ID | WP_006887487.1 |
| Coordinates | 2211346..2211639 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6I94_RS09670 | 2206585..2206812 | + | 228 | WP_128088010.1 | YdeI/OmpD-associated family protein | - |
| I6I94_RS09675 | 2206922..2207383 | + | 462 | WP_051121994.1 | DUF2867 domain-containing protein | - |
| I6I94_RS09680 | 2207380..2208114 | + | 735 | WP_006887454.1 | class I SAM-dependent methyltransferase | - |
| I6I94_RS09685 | 2208181..2208378 | + | 198 | WP_006887478.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| I6I94_RS09690 | 2208375..2208743 | + | 369 | WP_006887462.1 | type II toxin-antitoxin system VapC family toxin | - |
| I6I94_RS09695 | 2208879..2209124 | - | 246 | WP_006887449.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
| I6I94_RS09700 | 2209320..2210096 | - | 777 | WP_006887464.1 | alpha/beta hydrolase | - |
| I6I94_RS09705 | 2210099..2210638 | - | 540 | WP_039954902.1 | PadR family transcriptional regulator | - |
| I6I94_RS09710 | 2210849..2211346 | - | 498 | WP_006887455.1 | GNAT family N-acetyltransferase | Toxin |
| I6I94_RS09715 | 2211346..2211639 | - | 294 | WP_006887487.1 | DUF1778 domain-containing protein | Antitoxin |
| I6I94_RS09720 | 2211704..2211904 | - | 201 | WP_039954896.1 | hypothetical protein | - |
| I6I94_RS09725 | 2212033..2213493 | + | 1461 | WP_006887450.1 | hypothetical protein | - |
| I6I94_RS09730 | 2213649..2214608 | - | 960 | WP_006887442.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| I6I94_RS09735 | 2214924..2215289 | - | 366 | WP_006887446.1 | nuclear transport factor 2 family protein | - |
| I6I94_RS09740 | 2215386..2215988 | + | 603 | WP_128088009.1 | TetR/AcrR family transcriptional regulator | - |
| I6I94_RS09745 | 2215985..2216617 | - | 633 | WP_128088008.1 | DJ-1/PfpI family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18497.28 Da Isoelectric Point: 9.4063
>T186638 WP_006887455.1 NZ_CP068102:c2211346-2210849 [Rothia aeria]
MSLQKPRRLLKSDNLSDFESGAHDLDSWLHKFAWENQRAHNSVTYVATIGDRVVGYYALAAGSVQKAAVSKNFAQRRPHE
IPCILLARLAVDKRTRGQGIGTLLLRDALERTVSASETLGVAALLIHCRDEEAKKFYEYHADVLESPLDPFQLILPMKSI
RKLLG
MSLQKPRRLLKSDNLSDFESGAHDLDSWLHKFAWENQRAHNSVTYVATIGDRVVGYYALAAGSVQKAAVSKNFAQRRPHE
IPCILLARLAVDKRTRGQGIGTLLLRDALERTVSASETLGVAALLIHCRDEEAKKFYEYHADVLESPLDPFQLILPMKSI
RKLLG
Download Length: 498 bp
>T186638 NZ_CP089611:722587-722994 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11130.46 Da Isoelectric Point: 4.7574
>AT186638 WP_006887487.1 NZ_CP068102:c2211639-2211346 [Rothia aeria]
MSTTVKSQRINLRASERQEALIRQAAEVTDSSVSDFILSSATERAEHVLADRRWFVATEEQYDLFVQALEAPTRTEKLER
LFARESPVGKEIVFKED
MSTTVKSQRINLRASERQEALIRQAAEVTDSSVSDFILSSATERAEHVLADRRWFVATEEQYDLFVQALEAPTRTEKLER
LFARESPVGKEIVFKED
Download Length: 294 bp
>AT186638 NZ_CP089611:722330-722590 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|