Detailed information of TA system TA186627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3978461..3979086
• Replicon: chromosome
• Accession: NZ_CP068096
• Organism: Serratia plymuthica strain FDAARGOS_1138

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S4YKF9
• Locus tag: I6I95_RS18610
• Protein ID: WP_020439240.1
• Coordinates: 3978904..3979086 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: S4YHW4
• Locus tag: I6I95_RS18605
• Protein ID: WP_006326094.1
• Coordinates: 3978461..3978874 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I95_RS18575	3973690..3974412	+	723	WP_004945948.1	RNA polymerase sigma factor FliA	-
I6I95_RS18580	3974469..3974978	+	510	WP_004945946.1	flagella biosynthesis regulatory protein FliZ	-
I6I95_RS18585	3975104..3976096	+	993	WP_020439241.1	D-cysteine desulfhydrase	-
I6I95_RS18590	3976210..3977010	+	801	WP_006326095.1	cystine ABC transporter substrate-binding protein	-
I6I95_RS18595	3977010..3977672	+	663	WP_004945937.1	cystine ABC transporter permease	-
I6I95_RS18600	3977676..3978428	+	753	WP_004945934.1	L-cystine ABC transporter ATP-binding protein YecC	-
I6I95_RS18605	3978461..3978874	-	414	WP_006326094.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6I95_RS18610	3978904..3979086	-	183	WP_020439240.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6I95_RS18615	3979253..3983224	-	3972	WP_020439239.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
I6I95_RS18620	3983327..3983572	+	246	WP_020439238.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6891.13 Da
• Isoelectric Point: 11.0382

>T186627 WP_020439240.1 NZ_CP068096:c3979086-3978904 [Serratia plymuthica]
VKSAEPIRLLEREGWVLERIKGSHHQFKHPSSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T186627 NZ_CP089611:366496-366798 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15156.85 Da
• Isoelectric Point: 4.5728

>AT186627 WP_006326094.1 NZ_CP068096:c3978874-3978461 [Serratia plymuthica]
MFYPAYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSVVQQHPGYGSRSAFLAAAARNELLKVD

Nucleotide

• Length: 414 bp

>AT186627 NZ_CP089611:366272-366499 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Structures

Toxin

• AlphaFold DB: S4YKF9

Antitoxin

• AlphaFold DB: S4YHW4