Detailed information of TA system TA186626

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2766695..2767364
• Replicon: chromosome
• Accession: NZ_CP068096
• Organism: Serratia plymuthica strain FDAARGOS_1138

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: I6I95_RS12980
• Protein ID: WP_006327725.1
• Coordinates: 2766942..2767364 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: I6I95_RS12975
• Protein ID: WP_004952428.1
• Coordinates: 2766695..2766961 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I95_RS12950	2761820..2763145	+	1326	WP_020439700.1	MHS family MFS transporter	-
I6I95_RS12955	2763193..2763801	-	609	WP_004952444.1	HD domain-containing protein	-
I6I95_RS12960	2763992..2764669	+	678	WP_004952439.1	hemolysin III family protein	-
I6I95_RS12965	2764833..2765330	+	498	WP_020439699.1	DUF2165 domain-containing protein	-
I6I95_RS12970	2765384..2766370	-	987	WP_006327726.1	tRNA-modifying protein YgfZ	-
I6I95_RS12975	2766695..2766961	+	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
I6I95_RS12980	2766942..2767364	+	423	WP_006327725.1	protein YgfX	Toxin
I6I95_RS12985	2767364..2768059	+	696	WP_004952420.1	two-component system response regulator CreB	-
I6I95_RS12990	2768056..2769474	+	1419	WP_020439698.1	two-component system sensor histidine kinase CreC	-
I6I95_RS12995	2769559..2770923	+	1365	WP_004952415.1	cell envelope integrity protein CreD	-
I6I95_RS13000	2770961..2771479	-	519	WP_004952413.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T186626 WP_006327725.1 NZ_CP068096:2766942-2767364 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T186626 NZ_CP089611:71837-72238 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT186626 WP_004952428.1 NZ_CP068096:2766695-2766961 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT186626 NZ_CP089611:71605-71844 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10