Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 2060406..2060977 Replicon chromosome
Accession NZ_CP068096
Organism Serratia plymuthica strain FDAARGOS_1138

Toxin (Protein)


Gene name relE Uniprot ID S4YNR1
Locus tag I6I95_RS09795 Protein ID WP_020439916.1
Coordinates 2060406..2060684 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S4YTP6
Locus tag I6I95_RS09800 Protein ID WP_004951261.1
Coordinates 2060708..2060977 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I95_RS09775 2056572..2056910 - 339 WP_006328508.1 PTS lactose/cellobiose transporter subunit IIA -
I6I95_RS09780 2057266..2057835 + 570 WP_006328507.1 peptidylprolyl isomerase A -
I6I95_RS09785 2057995..2059680 + 1686 WP_006328506.1 sensor histidine kinase -
I6I95_RS09790 2059680..2060405 + 726 WP_004951264.1 two-component system response regulator BtsR -
I6I95_RS09795 2060406..2060684 - 279 WP_020439916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I95_RS09800 2060708..2060977 - 270 WP_004951261.1 hypothetical protein Antitoxin
I6I95_RS09805 2061207..2062733 + 1527 WP_006328494.1 DUF853 family protein -
I6I95_RS09810 2062839..2063414 + 576 WP_006328493.1 aminodeoxychorismate synthase component II -
I6I95_RS09815 2063546..2064763 + 1218 WP_004951256.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10242.84 Da        Isoelectric Point: 8.5141

>T186625 WP_020439916.1 NZ_CP068096:c2060684-2060406 [Serratia plymuthica]
VTLKWTEPAIADRIAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T186625 NZ_CP089610:3835669-3836079 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10364.70 Da        Isoelectric Point: 7.0169

>AT186625 WP_004951261.1 NZ_CP068096:c2060977-2060708 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Download         Length: 270 bp

>AT186625 NZ_CP089610:3835394-3835672 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4YNR1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KXK3

References