Detailed information of TA system TA186624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1179478..1181101
• Replicon: chromosome
• Accession: NZ_CP068096
• Organism: Serratia plymuthica strain FDAARGOS_1138

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6I95_RS05730
• Protein ID: WP_041417521.1
• Coordinates: 1179478..1180800 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: S4YPP9
• Locus tag: I6I95_RS05735
• Protein ID: WP_020438366.1
• Coordinates: 1180805..1181101 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I95_RS05720	1176155..1178161	+	2007	WP_020438369.1	DEAD/DEAH box helicase	-
I6I95_RS05725	1178163..1179422	+	1260	WP_020438368.1	GIY-YIG nuclease family protein	-
I6I95_RS05730	1179478..1180800	-	1323	WP_041417521.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6I95_RS05735	1180805..1181101	-	297	WP_020438366.1	helix-turn-helix transcriptional regulator	Antitoxin
I6I95_RS05740	1181309..1181944	-	636	WP_020438365.1	carbonic anhydrase	-
I6I95_RS05745	1182878..1183438	+	561	WP_006323369.1	hypothetical protein	-
I6I95_RS05750	1183751..1184073	-	323	Protein_1115	DNA-binding transcriptional regulator	-
I6I95_RS05755	1184057..1184194	-	138	WP_100220743.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6I95_RS05765	1184904..1185182	+	279	WP_144080223.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49907.03 Da
• Isoelectric Point: 6.8707

>T186624 WP_041417521.1 NZ_CP068096:c1180800-1179478 [Serratia plymuthica]
MRRSQQRLAIWMNSIPVGYWEKRKGEDRLEYLPGWIADNQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRFHAESLDPFDLLTELGRDCVGAIQLLDIDEQPTHIFSIRQRPLSEAQIAEMLRNTATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNRWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDGQWWIRLPQEDMCQALGVSPLKKYQSDGGPGITDIMEVLSRSDQAETDRRRFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNSQIAWQKCKLAMAVRGSSNYYHISQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIDLVAGLLPDSFSPELAACIFDGIRQQCARLKGR

Nucleotide

• Length: 1323 bp

>T186624 NZ_CP089610:c3808640-3808248 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10965.46 Da
• Isoelectric Point: 8.0099

>AT186624 WP_020438366.1 NZ_CP068096:c1181101-1180805 [Serratia plymuthica]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEVVLSSELTSPGCE
TEDTSTTHIDSPARREQW

Nucleotide

• Length: 297 bp

>AT186624 NZ_CP089610:c3808915-3808640 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Structures

Antitoxin

• AlphaFold DB: S4YPP9