186623

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 537020..537642 Replicon chromosome
Accession NZ_CP068096
Organism Serratia plymuthica strain FDAARGOS_1138

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag I6I95_RS02705 Protein ID WP_006322256.1
Coordinates 537439..537642 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag I6I95_RS02700 Protein ID WP_004949348.1
Coordinates 537020..537388 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I95_RS02670 533062..533316 + 255 WP_004949355.1 type B 50S ribosomal protein L31 -
I6I95_RS02675 533329..533469 + 141 WP_004949353.1 type B 50S ribosomal protein L36 -
I6I95_RS02680 533584..534462 - 879 WP_006323980.1 metal ABC transporter substrate-binding protein -
I6I95_RS02685 534488..535345 - 858 WP_004949351.1 metal ABC transporter permease -
I6I95_RS02690 535342..536055 - 714 WP_006323974.1 ABC transporter ATP-binding protein -
I6I95_RS02695 536507..536860 + 354 WP_004949349.1 hypothetical protein -
I6I95_RS02700 537020..537388 + 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
I6I95_RS02705 537439..537642 + 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
I6I95_RS02710 537882..538418 - 537 WP_006323971.1 cytochrome b/b6 domain-containing protein -
I6I95_RS02715 538479..539900 - 1422 WP_020438550.1 N-acetylglucosamine-binding protein GbpA -
I6I95_RS02720 540180..540554 + 375 WP_006323969.1 type II secretion system pilot lipoprotein GspS -
I6I95_RS02725 540551..541381 - 831 WP_006323964.1 A24 family peptidase -
I6I95_RS02730 541414..541875 - 462 WP_006323963.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T186623 WP_006322256.1 NZ_CP068096:537439-537642 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T186623 NZ_CP089610:3781399-3781656 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT186623 WP_004949348.1 NZ_CP068096:537020-537388 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT186623 NZ_CP089610:3781127-3781402 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References