Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 49529..50054 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP068091 | ||
| Organism | Shigella boydii strain FDAARGOS_1139 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | Q326Z8 |
| Locus tag | I6I96_RS22530 | Protein ID | WP_001159860.1 |
| Coordinates | 49749..50054 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | Q7BEK0 |
| Locus tag | I6I96_RS22525 | Protein ID | WP_000813626.1 |
| Coordinates | 49529..49747 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6I96_RS22490 | 44678..44938 | + | 261 | Protein_52 | IS1 family transposase | - |
| I6I96_RS22495 | 44978..45097 | - | 120 | Protein_53 | transposase domain-containing protein | - |
| I6I96_RS22500 | 45323..46915 | - | 1593 | WP_001072385.1 | IS66 family transposase | - |
| I6I96_RS22505 | 46946..47296 | - | 351 | WP_000624671.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| I6I96_RS22510 | 47293..47589 | - | 297 | WP_072072579.1 | transposase | - |
| I6I96_RS22515 | 47676..48844 | + | 1169 | WP_134810631.1 | IS3 family transposase | - |
| I6I96_RS22520 | 48956..49150 | - | 195 | WP_000872577.1 | hypothetical protein | - |
| I6I96_RS22525 | 49529..49747 | + | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| I6I96_RS22530 | 49749..50054 | + | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| I6I96_RS22535 | 50078..50185 | + | 108 | WP_023592908.1 | transposase domain-containing protein | - |
| I6I96_RS22540 | 50447..52084 | + | 1638 | WP_039060807.1 | T3SS effector E3 ubiquitin-protein ligase IpaH9.8 | - |
| I6I96_RS22545 | 52292..52561 | + | 270 | WP_000079956.1 | hypothetical protein | - |
| I6I96_RS22550 | 52558..52730 | + | 173 | Protein_64 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6I96_RS22555 | 52794..53491 | - | 698 | Protein_65 | IS1 family transposase | - |
| I6I96_RS22560 | 53698..53814 | + | 117 | WP_004996477.1 | hypothetical protein | - |
| I6I96_RS22565 | 54178..55020 | + | 843 | WP_000931198.1 | polysaccharide deacetylase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ipaH1.4 / ipaH4.5 / ipaH7.8 / ospD3/senA / ospC1 / senB / ospE2 / ipaH9.8 / ospC2 / nleE / icsP/sopA / ospB / ospC4 / ospD2 / ospF / ospD1 / ipgB2 | 1..122799 | 122799 | |
| - | inside | IScluster/Tn | - | ospE2 / ipaH9.8 | 30781..59419 | 28638 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11736.59 Da Isoelectric Point: 6.4674
>T186619 WP_001159860.1 NZ_CP068091:49749-50054 [Shigella boydii]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T186619 NZ_CP089610:3187107-3187370 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8333.36 Da Isoelectric Point: 6.2838
>AT186619 WP_000813626.1 NZ_CP068091:49529-49747 [Shigella boydii]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW
Download Length: 219 bp
>AT186619 NZ_CP089610:3186822-3187103 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P7TTN3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7BEK0 |