Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1961176..1961807 Replicon chromosome
Accession NZ_CP068090
Organism Shigella boydii strain FDAARGOS_1139

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag I6I96_RS09880 Protein ID WP_001259385.1
Coordinates 1961532..1961807 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag I6I96_RS09875 Protein ID WP_000593554.1
Coordinates 1961176..1961535 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I96_RS09850 1957308..1958252 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
I6I96_RS09855 1958249..1959082 + 834 WP_001008950.1 nickel ABC transporter permease subunit NikC -
I6I96_RS09860 1959082..1959846 + 765 WP_001136224.1 nickel import ATP-binding protein NikD -
I6I96_RS09865 1959843..1960649 + 807 WP_000173706.1 nickel import ATP-binding protein NikE -
I6I96_RS09870 1960655..1961056 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
I6I96_RS09875 1961176..1961535 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6I96_RS09880 1961532..1961807 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
I6I96_RS09885 1961880..1963004 - 1125 WP_001216257.1 ABC transporter permease -
I6I96_RS09890 1963004..1965739 - 2736 WP_000149139.1 ribosome-associated ATPase/putative transporter RbbA -
I6I96_RS09895 1965736..1966803 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T186608 WP_001259385.1 NZ_CP068090:c1961807-1961532 [Shigella boydii]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T186608 NZ_CP089610:c2865777-2865358 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT186608 WP_000593554.1 NZ_CP068090:c1961535-1961176 [Shigella boydii]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT186608 NZ_CP089610:c2865998-2865774 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References