Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2122185..2122696 Replicon chromosome
Accession NZ_CP068079
Organism Staphylococcus carnosus strain FDAARGOS_1147

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag I6J04_RS10400 Protein ID WP_015900832.1
Coordinates 2122490..2122696 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag I6J04_RS10395 Protein ID WP_015900833.1
Coordinates 2122185..2122478 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6J04_RS10370 2117557..2118195 + 639 WP_046100516.1 thiamine phosphate synthase -
I6J04_RS10375 2118284..2119153 + 870 WP_015900837.1 membrane protein insertase YidC -
I6J04_RS10380 2119264..2119776 + 513 WP_046100517.1 GNAT family N-acetyltransferase -
I6J04_RS10385 2119867..2120514 - 648 WP_046100518.1 HD domain-containing protein -
I6J04_RS10390 2120539..2122020 - 1482 WP_046100519.1 cardiolipin synthase -
I6J04_RS10395 2122185..2122478 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6J04_RS10400 2122490..2122696 + 207 WP_015900832.1 cation transporter Toxin
I6J04_RS10405 2122711..2122920 + 210 WP_046100520.1 copper ion binding protein -
I6J04_RS10410 2123017..2125218 + 2202 WP_046100521.1 heavy metal translocating P-type ATPase -
I6J04_RS10415 2125294..2125434 + 141 WP_167313208.1 hypothetical protein -
I6J04_RS10420 2125506..2126723 - 1218 WP_046100522.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T186600 WP_015900832.1 NZ_CP068079:2122490-2122696 [Staphylococcus carnosus]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T186600 NZ_CP089610:c2230580-2230161 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT186600 WP_015900833.1 NZ_CP068079:2122185-2122478 [Staphylococcus carnosus]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT186600 NZ_CP089610:c2230849-2230589 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References